Erythrocyte-enabled immunomodulation for vaccine delivery
Erythrocyte-enabled immunomodulation for vaccine delivery
复制标题
用于疫苗递送的红细胞免疫调节
DOI：
10.1016/j.jconrel.2021.11.035
复制
发表时间：
2022
影响因子：
10.8
通讯作者：
Gang Chen
中科院分区：
文献类型：
--
作者：
Fei Wang;Rongling Zong;Gang Chen
红细胞在循环中捕获病原体并将其呈递到脾脏中的抗原呈递细胞（APCs）。衰老或凋亡的红细胞被脾apc以非炎症的方式生理性清除，不诱导免疫反应，而受损的红细胞往往诱导免疫激活。红细胞在其生命周期或不同状态下的独特特征激发了靶向脾APCs用于疫苗递送的设计。具体来说，正常或受损的红细胞驱动的免疫靶向可以诱导抗原特异性免疫激活，而衰老或凋亡的红细胞可以定制以实现抗原特异性免疫耐受。最近的研究揭示了以红细胞为基础的疫苗递送的潜力；然而，目前还没有深入的综述来描述最新的进展。本文综述了红细胞在不同状态下的特点、不同的免疫功能、不同的疫苗传递行为和生物医学应用。本文综述旨在为合理设计和开发以红细胞为基础的疫苗递送系统，以治疗各种感染、肿瘤、炎症性疾病和自身免疫性疾病做出贡献。
Erythrocytes capture pathogens in circulation and present them to antigen-presenting cells (APCs) in the spleen. Senescent or apoptotic erythrocytes are physiologically eliminated by splenic APCs in a non-inflammatory manner as to not induce an immune reaction, while damaged erythrocytes tend to induce immune activation. The distinct characteristics of erythrocytes in their lifespan or different states inspire the design of targeting splenic APCs for vaccine delivery. Specifically, normal or damaged erythrocyte-driven immune targeting can induce antigen-specific immune activation, whereas senescent or apoptotic erythrocytes can be tailored to achieve antigen-specific immune tolerance. Recent studies have revealed the potential of erythrocyte-based vaccine delivery; however, there is still no in-depth review to describe the latest progress. This review summarizes the characteristics, different immune functions, and diverse vaccine delivery behaviors and biomedical applications of erythrocytes in different states. This review aims to contribute to the rational design and development of erythrocyte-based vaccine delivery systems for treating various infections, tumors, inflammatory diseases, and autoimmune diseases.