Dietary patterns and the risk of coronary heart disease in women
Dietary patterns and the risk of coronary heart disease in women
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DOI：
10.1001/archinte.161.15.1857
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发表时间：
2001-08-13
影响因子：
--
通讯作者：
Hu, FB
中科院分区：
文献类型：
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作者：
Fung, TT;Willett, WC;Hu, FB
背景资料：虽然关于个别营养素或食物与冠心病（CHD）风险的大量信息是可用的，但对整体饮食模式的作用知之甚少。方法：利用1984年护士健康研究中食物频率问卷的饮食信息，我们进行了因素分析，确定了两种主要的饮食模式-“谨慎”和“西方”-并计算了群组中个体的每种模式的因子得分。我们采用逻辑回归法对1984年69017名年龄在38 - 63岁之间、无主要慢性病史的女性进行了前瞻性研究，以探讨饮食模式与冠心病风险之间的关系。谨慎模式的特点是水果、蔬菜、豆类、鱼、家禽和全谷物的摄入量较高，而西方模式的特点是红肉和加工肉类的摄入量较高，糖果和甜点、炸薯条和精制谷物。在1984年至1996年期间，我们记录了821例CHD病例。调整冠状动脉风险因素后，将最高和最低五分位数进行比较，谨慎饮食评分与0.76的相对风险（RR）相关（95%置信区间（CI），0.60-0.98;趋势检验P，0.03）。极端五分位数比较得出，西方模式的RR为1.46（95% CI，1.07-1.99;趋势检验P，0.02）。那些谁是联合在最高谨慎饮食五分之一和最低西方饮食五分之一的RR为0.64（95%CI，0.44-0.92）相比，与那些相反的模式profile.Conclusion：饮食高水果，蔬菜，全谷物，豆类，家禽，鱼类和低精制谷物，土豆，红色和加工肉类可能降低冠心病的风险。
Background: Although substantial information on individual nutrients or foods and risk of coronary heart disease (CHD) is available, little is known about the role of overall eating pattern.Methods: Using dietary information from a food frequency questionnaire in 1984 from the Nurses' Health Study, we conducted factor analysis and identified 2 major dietary pattems - "prudent" and "Western" - and calculated factor scores of each pattern for individuals in the cohort. We used logistic regression to examine prospectively the associations between dietary patterns and CHD risk among 69017 women aged 38 to 63 years in 1984 without history of major chronic diseases.Results: The prudent pattern was characterized by higher intakes of fruits, vegetables, legumes, fish, poultry, and whole grains, while the Western pattern was characterized by higher intakes of red and processed meats, sweets and desserts, french fries, and refined grains. Between 1984 and 1996, we documented 821 CHD cases. After adjusting for coronary risk factors, the prudent diet score was associated with a relative risk (RR) of 0.76 (95% confidence interval (CI), 0.60-0.98; P for trend test,.03) comparing the highest with lowest quintile. Extreme quintile comparison yielded,an RR of 1.46 (95% CI, 1.07-1.99; P for trend test,.02) for the Western pattern. Those who were jointly in the highest prudent diet quintile and lowest Western diet quintile had an RR of 0.64 (95% CI, 0.44-0.92) compared with those with the opposite pattern profile.Conclusion: A diet high in fruits, vegetables, whole grains, legumes, poultry, and fish and low in refined grains, potatoes, and red and processed meats may lower risk of CHD.