Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus-Infected Homosexual Man
Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus-Infected Homosexual Man
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DOI：
10.1053/j.gastro.2014.05.010
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发表时间：
2014-09-01
期刊：
影响因子：
29.4
通讯作者：
Angel Martinez, Miguel
中科院分区：
文献类型：
--
作者：
Franco, Sandra;Tural, Cristina;Angel Martinez, Miguel
丙型肝炎病毒（HCV）感染在感染人类免疫缺陷病毒的男男性行为者中流行。对最近批准的直接作用抗病毒药物（DAA）具有耐药性的HCV变体的传播可能是一个重要的临床和公共卫生问题。我们记录了一例从接受特拉匹韦治疗的患者向其性伴侣传播DAA耐药HCV变体的病例。HCV DAA耐药变异体的传播可能会损害包括DAA在内的治疗方案。
There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.