Colonic motor activity in acute colitis in conscious dogs.
Colonic motor activity in acute colitis in conscious dogs.
复制标题
清醒犬急性结肠炎的结肠运动活动。
DOI：
10.1016/0016-5085(91)90269-q
复制
发表时间：
1991
期刊：
影响因子：
29.4
通讯作者：
Sarna,SK
中科院分区：
文献类型：
--
作者：
Sethi,AK;Sarna,SK
在六只清醒的狗中研究了急性结肠炎期间结肠运动活动的变化。用7个应变计传感器记录运动活动。通过醋酸腔灌注在整个结肠中诱发结肠炎。在结肠炎期间，犬表现出尿急和腹泻，伴有粘液和血液。粘膜弥漫性肿胀且易碎，粘膜表面有散在溃疡。结肠炎期间结肠运动活动发生了几种变化：（a）每小时总持续时间和收缩状态的平均持续时间显著减少;（B）结肠移行性运动复合波的周期长度显著延长，非移行性运动复合波几乎完全消失;（d）巨大移行性收缩的发生率显著增加。大约有一半的巨大迁移性宫缩伴随着排便。剩下的排出粘液或气体。有时，结肠中的移行性运动复合体也伴随着排便;这在正常状态下从未观察到。诱导结肠炎后21天，结肠运动活动仍减少，周期延长。然而，此时犬无症状，结肠镜检查时粘膜正常。巨大游走性宫缩的发生率在此时也是正常的。结论是，由于犬的症状与人溃疡性结肠炎相似，因此犬是研究结肠炎的良好模型。结肠炎期间结肠的阶段性收缩减少，但巨大移行性收缩的发生率增加。结肠炎的腹泻可能主要是由于中段和远端结肠大量巨大的移行性收缩造成的。
The changes in motor activity of the colon during acute colitis were investigated in six conscious dogs. The motor activity was recorded with seven straingauge transducers. Colitis was induced in the entire colon by luminal perfusion of acetic acid. The dogs exhibited urgency and diarrhea with mucus and blood during colitis. The mucosa was diffusely erythematous and friable and there were scattered ulcerations over the mucosal surface. The motor activity of the colon changed in several ways during colitis: (a) the total duration per hour and the mean duration of contractile states decreased significantly; (b) the cycle length of colonic migrating motor complexes was significantly prolonged, and the nonmigrating motor complexes were almost completely absent; and (d) the incidence of giant migrating contractions increased significantly. About half of the giant migrating contractions were followed by defecation. The remaining expelled mucus or gas. Sometimes, a migrating motor complex in the colon was also followed by defecation; this was never observed in the normal state. The motor activity of the colon was still decreased and the cycle length prolonged 21 days after induction of colitis. However, the dogs were asymptomatic at this time and the mucosa looked normal at colonoscopy. The incidence of giant migrating contractions was also normal at this time. It was concluded that the dog is a good model for the study of colitis because of the similarity of symptoms with human ulcerative colitis. The phasic contractions of the colon decreases during colitis but the incidence of giant migrating contractions is increased. The diarrhea in colitis may primarily be due to the large number of giant migrating contractions in the middle and the distal colon.