Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery
Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery
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DOI：
10.1016/s0959-8049(01)00318-5
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发表时间：
2001-12-01
影响因子：
8.4
通讯作者：
Tsigris, C
中科院分区：
文献类型：
--
作者：
Alexiou, D;Karayiannakis, AJ;Tsigris, C
采用酶联免疫吸附试验（ELISA）检测63例大肠癌患者和51例正常人血清中细胞粘附分子E-选择素、细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）的浓度。它们与临床病理变量和患者生存率的关系以及手术后它们的水平变化进行了研究。大肠癌患者血清E-选择素、ICAM-1和VCAM-1水平显著高于健康对照组。两者之间有着显著的关联。这些分子的血清水平、疾病阶段以及淋巴结和远处转移的存在。ICAM-1和VCAM-1水平与血清E-选择素和癌胚抗原（CEA）水平相关。所有三种分子的血清水平显着降低后，根治性切除肿瘤。术前E-选择素升高。ICAM-1和VCAM-1水平是重要的预后因素，虽然不是独立的阶段。病人的生存。这些结果表明，血清中E-选择素，ICAM-1和VCAM-1的浓度可能反映肿瘤的进展和转移。由于这些标记物与CEA水平有关，因此尚不确定它们的测量是否会证明在结直肠癌管理中具有成本效益。(C)2001爱思唯尔科技有限公司版权所有。
The serum concentrations oft he cell adhesion molecules E-select in, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 63 patients with colorectal cancer and in 51 controls by an enzyme-linked immunosorbent assay (ELISA). Their relationship to clinicopathological variables and patient survival and changes in their levels after surgery were examined. Colorectal cancer patients showed significantly higher serum levels of E-selectin, ICAM-1 and VCAM-1 compared with healthy controls. There was a significant association between. the serum levels of these molecules, disease stage and the presence of both lymph node and distant metastases. Both ICAM-1 and VCAM-1 levels correlated with serum E-selectin and carcinoembryonic antigen (CEA) levels. Serum levels of all three molecules decreased significantly after radical resection of the tumour. Elevated pre-operative E-selectin. ICAM-1 and VCAM-1 levels were significant prognostic factors, although not independent of stage. for patient survival. These findings suggest that serum concentrations of E-selectin, ICAM-1 and VCAM-1 may reflect tumour progression and metastasis. Since these markers are linked to CEA levels, it is uncertain whether their measurement will prove cost-effective in colorectal cancer management. (C) 2001 Elsevier Science Ltd. All rights reserved.