Case of primary anorectal malignant melanoma treated with adjuvant immunotherapy
Case of primary anorectal malignant melanoma treated with adjuvant immunotherapy
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原发性肛门直肠恶性黑色素瘤辅助免疫治疗一例
DOI：
10.1111/1346-8138.15585
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
M. Ohtsuki
中科院分区：
文献类型：
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作者：
Soichiro Kado;T. Maekawa;K. Kamiya;M. Komine;S. Murata;M. Ohtsuki
其他为伴表皮性的卫星转移性病变，通过淋巴流传播。6个月过去了，没有复发或转移。黑色素瘤表皮性转移的特点是晚期患者突然出现弥散性小色斑。相反，本病例表现为缓慢生长的肿胀丘疹，临床病程缓慢。此外，临床表现与原发病变难以区分。虽然EM的机制尚未明确，但嗜表皮性通常是在表现出侵袭性行为的肿瘤细胞中获得的。本病例的临床病理特征表明，具有温顺性的肿瘤细胞也可能获得表皮性，并且卫星转移灶发展为特征性的肿胀丘疹。在出现类似丘疹聚集的病例中，应考虑黑色素瘤伴卫星电镜的可能性作为鉴别诊断。
others as satellite metastatic lesions with epidermotropism which spread via lymphatic flow. Six months have now passed without recurrence or metastasis. Epidermotropic metastasis of melanoma has been characterized as sudden development of disseminated small-sized pigmented macules in advanced-stage patients. In contrast, the present case showed slowly growing agminated papules with an indolent clinical course. Moreover, the clinical appearance was indistinguishable from the primary lesion. While the mechanism of EM has yet to be clarified, epidermotropism is usually acquired in tumor cells showing aggressive behavior. The clinicopathological features of the present case suggested that tumor cells with a docile nature may also acquire epidermotropism, and the satellite metastases had developed characteristic agminated papules. The possibility of melanoma with satellite EM should be considered as a differential diagnosis in cases with aggregation of similarly appearing papules.