Interstudy Variability in Cardiac Magnetic Resonance Imaging Measurements of Ventricular Volume, Mass, and Ejection Fraction in Repaired Tetralogy of Fallot: A Prospective Observational Study
Interstudy Variability in Cardiac Magnetic Resonance Imaging Measurements of Ventricular Volume, Mass, and Ejection Fraction in Repaired Tetralogy of Fallot: A Prospective Observational Study
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DOI：
10.1002/jmri.24050
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发表时间：
2013-10-01
影响因子：
4.4
通讯作者：
Prakash, Ashwin
中科院分区：
文献类型：
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作者：
Blalock, Shannon E.;Banka, Puja;Prakash, Ashwin
PurposeTo评估心脏磁共振成像（CMR）参数的心室大小和功能的修复法洛四联症（TOF）的研究间变异性Materials and MethodsTOF患者（n = 30，中位年龄23.5岁，43%男性）被前瞻性招募。每例患者在同一天接受两次连续CMR检查。每个检查分析心室大小和功能的两个观察员和多重比较进行了评估协议使用Bland-Altman分析和组内相关系数（ICC）。ResultsAgreement心室大小和功能的大多数措施是高时，一个单一的观察员分析这两项研究。当不同的观察者分析连续研究时，一致性更差。这种影响在右心室（RV）质量测量中最为突出，在收缩期测量质量时略有改善。除了心室质量，协议是相似的RV和左心室（LV）parameters.ConclusionCMR措施的心室大小和功能有可接受的重复性，在修复TOF患者的系列检查。RV质量的测量值具有较高的变异性。对于大多数参数，当由多个操作员进行测量时，一致性限值更宽。这些结果将有助于解释个体患者随访中的研究间差异和设计未来的临床试验。J. Magn. Reson. Imaging 2013;38：829-835. (c)2013威利期刊公司
PurposeTo assess the interstudy variability of cardiac magnetic resonance imaging (CMR) parameters of ventricular size and function in repaired tetralogy of Fallot (TOF).Materials and MethodsPatients with TOF (n = 30, median age 23.5 years, 43% male) were enrolled prospectively. Each patient underwent two consecutive CMR examinations on the same day. Each examination was analyzed for ventricular size and function by two observers and multiple comparisons were made with assessment of agreement using Bland-Altman analysis and intraclass correlation coefficients (ICC).ResultsAgreement for most measures of ventricular size and function was high when a single observer analyzed both studies. Agreement was worse when different observers analyzed sequential studies. This effect was most prominent on measurements of right ventricular (RV) mass and there was slight improvement when mass was measured during systole. Aside from ventricular mass, agreement was similar for RV and left ventricular (LV) parameters.ConclusionCMR measures of ventricular size and function have acceptable repeatability across serial examinations in patients with repaired TOF. Measurements of RV mass are subject to higher variability. For most parameters, agreement limits are wider when measurements are performed by multiple operators. These results will aid in the interpretation of study-to-study variations in the follow-up of individual patients and in designing future clinical trials. J. Magn. Reson. Imaging 2013;38:829-835. (c) 2013 Wiley Periodicals, Inc.