DRUG-INDUCED CUTANEOUS REACTIONS A REPORT FROM THE BOSTON COLLABORATIVE DRUG SURVEILLANCE PROGRAM ON 15438 CONSECUTIVE INPATIENTS 1975 TO 1982
DRUG-INDUCED CUTANEOUS REACTIONS A REPORT FROM THE BOSTON COLLABORATIVE DRUG SURVEILLANCE PROGRAM ON 15438 CONSECUTIVE INPATIENTS 1975 TO 1982
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DOI：
10.1001/jama.256.24.3358
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发表时间：
1986-01-01
影响因子：
--
通讯作者：
ARNDT K
中科院分区：
文献类型：
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作者：
BIGBY M;JICK S;ARNDT K
我们分析了1975年6月至1982年6月期间由波士顿合作药物监测计划监测的15，438名连续住院患者的数据，以确定自1975年以来对药物的过敏性皮肤反应的发生率，并证实和扩展了先前22，227名患者的早期研究结果。347例患者发生了358例反应，患者的总体反应率为2.2%。每位患者平均接受了8种不同的药物。皮疹归因于51种药物，75%的过敏性皮肤反应归因于抗体、血液制品和吸入性粘液溶解剂。阿莫西林（每1000例暴露患者中有51.4例反应）、甲氧苄啶-磺胺甲恶唑（33.8/1000）和氨苄西林（33.2/1000）的反应率最高。药物特异性反应率范围为0至51.4/1000，并确定了180种药物或药物组。这些结果为医生提供了定量数据，这将有助于临床决策时，药物引起的皮疹，荨麻疹，或全身瘙痒症发生。
We analyzed the data on 15,438 consecutive medical inpatients monitored by the Boston Collaborative Drug Surveillance Program from June 1975 to June 1982 to determine the rates of allergic cutaneous reactions to drugs introduced since 1975 and to confirm and extend findings from an earlier study of the preceding 22,227 patients. There were 358 reactions occurring in 347 patients, for an overall reaction rate among patients of 2.2%. Each patient received a mean of eight different drugs. Rashes were attributed to 51 drugs, and 75% of the allergic cutaneous reactions were attributed to antibodies, blood products, and inhaled mucolytics. Amoxicillin (51.4 reactions per 1000 patients exposed), trimethoprim-sulfamethoxazole (33.8/1000), and ampicillin (33.2/1000) had the highest reaction rates. Drug-specific reaction rates ranged from zero to 51.4 per 1000 and were determined for 180 drugs or drug groups. These results provide physicians with quantitative data that will be helpful in clinical decision making when drug-induced exanthems, urticaria, or generalized pruritus occurs.