Test characteristics of the 15-item geriatric depression scale and Hamilton Depression Rating Scale in Parkinson disease
Test characteristics of the 15-item geriatric depression scale and Hamilton Depression Rating Scale in Parkinson disease
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DOI：
10.1097/01.jgp.0000192488.66049.4b
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发表时间：
2006-02-01
影响因子：
7.2
通讯作者：
Stern, MB
中科院分区：
文献类型：
--
作者：
Weintraub, D;Oehlberg, KA;Stern, MB
目的：本研究的目的是比较15项老年抑郁量表（GDS-15）和汉密尔顿抑郁评定量表（HDRS）在帕金森病（PD）患者中的敏感性、特异性和诊断准确性。方法：方便抽样148例接受专科治疗的特发性PD门诊患者，完成GDS-15量表，由研究精神病学家或经过培训的研究助理进行HDRS和第四版《精神障碍诊断与统计手册》抑郁模块结构化临床访谈。以抑郁障碍的SCID诊断为状态变量，绘制GDS-15和HDRS评分的受试者工作特征（ROC）曲线。结果：32名受试者（22%）被诊断为抑郁症。GDS-15和HDRS的判别效度均较高（ROC曲线下面积分别为0.92和0.91），GDS-15的判别效度最高为4/5（准确率87%，灵敏度88%，特异性85%），HDRS的判别效度最高为9/10（准确率83%，灵敏度88%，特异性78%）。结论：GDS-15作为一种筛查工具，在区分PD患者的抑郁和非抑郁方面表现良好。其测试特性可与HDRS媲美。因为它是一个简单的工具，可以自我管理，它是一个很好的抑郁症筛查工具在这一人群。
Objective: The objective of this study was to compare the sensitivity, specificity, and diagnostic accuracy of the 15-item Geriatric Depression Scale (GDS-15) and the Hamilton Depression Rating Scale (HDRS) in patients with Parkinson disease (PD). Method: A convenience sample of 148 outpatients with idiopathic PD receiving specialty care completed the GDS-15 and were administered the HDRS and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID) depression module by a research psychiatrist or trained research assistant. Receiver-operating characteristic (ROC) curves were plotted for the GDS-15 and HDRS scores with a SCID diagnosis of a depressive disorder as the state variable. Results: Thirty-two subjects (22%) were diagnosed with a depressive disorder. The discriminant validity of the GDS-15 and HDRS were both high (ROC area under the curve: 0.92 and 0.91, respectively), with greatest dichotomization for the GDS-15 at a cutoff of 4/5 (87% accuracy, 88% sensitivity, 85% specificity) and the HDRS at a cutoff of 9/10 (83% accuracy, 88% sensitivity, 78% specificity). Conclusions: The GDS-15 performs well as a screening instrument and in distinguishing depressed from nondepressed patients in PD. Its test characteristics are comparable to the HDRS. Because it is a brief instrument and can be self-administered, it is an excellent depression screening tool in this population.