Here come the septins: novel polymers that coordinate intracellular functions and organization
Here come the septins: novel polymers that coordinate intracellular functions and organization
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DOI：
10.1242/jcs.02746
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发表时间：
2006-01-01
影响因子：
4
通讯作者：
Nelson, WJ
中科院分区：
文献类型：
--
作者：
Spiliotis, ET;Nelson, WJ
Septins是一种保守的GTP结合蛋白，与细胞膜、肌动蛋白和微管细胞骨架相关。它们聚集形成丝状结构，作为不同膜结构域之间的扩散屏障，并作为膜和细胞因子结合蛋白的分子支架。在酵母中，septins是膜极性和细胞分裂的时空协调的核心，但其哺乳动物对应物的作用仍然知之甚少。然而，最近的研究结果揭示了哺乳动物septin组装的动力学和调节，以及我们对septin在细胞骨架和膜组织中的功能的理解。哺乳动物septins似乎形成了一种新型的多聚体网络，该网络是多功能的，可互换的，并且动态地响应于在细胞骨架和膜生物学之间的界面处协调事件的信号。因此，对这些分子的研究不仅可以为细胞如何协调其功能提供新的见解，还可以为癌症和其他septins异常表达的疾病的发病机制提供新的见解。
Septins are conserved GTP-binding proteins that associate with cellular membranes and the actin and microtubule cytoskeletons. They polymerize to form filamentous structures that act as diffusion barriers between different membrane domains and as molecular scaffolds for membrane- and cytoskeleton-binding proteins. In yeast, septins are central to the spatio-temporal coordination of membrane polarity and cell division, but the roles of their mammalian counterparts have remained poorly understood. However, recent findings have shed light on the dynamics and regulation of mammalian septin assembly and our understanding of septin functions in cytoskeleton and membrane organization. The mammalian septins appear to form a novel network of hetero-polymers that are multi-functional, inter-changeable and respond dynamically to signals that coordinate events at the interface between cytoskeleton and membrane biology. Hence, studies of these molecules might provide new insights not only into how cells coordinate their functions, but also into the pathogenesis of cancer and other diseases in which septins are abnormally expressed.