The N-end rule: Functions, mysteries, uses
The N-end rule: Functions, mysteries, uses
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DOI：
10.1073/pnas.93.22.12142
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发表时间：
1996-10-29
影响因子：
11.1
通讯作者：
Varshavsky, A
中科院分区：
文献类型：
--
作者：
Varshavsky, A
N-端规则将蛋白质在体内的半衰期与其N-端残基的同一性联系起来。类似但不同版本的N末端规则适用于所有被研究的生物体，从哺乳动物到真菌和细菌。在真核生物中，N-端调控通路是泛素系统的一部分。我讨论了这个途径的机制和功能，并考虑了它的应用。
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.