Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma
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DOI：
10.2169/internalmedicine.2993-19
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发表时间：
2020-01-01
影响因子：
1.2
通讯作者：
Takano, Hideki
中科院分区：
文献类型：
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作者：
Higashihara, Takaaki;Okada, Akira;Takano, Hideki
我们对一位患有肺鳞状细胞癌的肾病综合征患者进行了肾活检。这会使预后恶化放化疗对肿瘤及蛋白尿有效，推测肾病综合征与肿瘤密切相关。肾脏的病理分析显示λ链的单克隆性，满足单克隆免疫球蛋白沉积的增殖性肾小球肾炎（PGNMID）的诊断标准;然而，未观察到明显的系膜增殖。这是第一例PGNMID合并肺癌;此外，我们的研究结果强调了检查肾脏病变和评估癌症患者单克隆性的重要性。
We performed a renal biopsy for nephrotic syndrome in a patient with squamous cell lung carcinoma. which can worsen the prognosis. Chemoradiation therapy was effective for the cancer and proteinuria; we thus inferred that the nephrotic syndrome had been closely associated with the carcinoma. A pathological analysis of the kidney showed monoclonality for lambda chain, satisfying the diagnostic criteria of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID); however, conspicuous mesangial proliferation was not observed. This is the first case of PGNMID complicated with lung carcinoma; furthermore, our findings underscore the importance of examining renal lesions and assessing monoclonality in cancer patients.