Muscularization of the Mesenchymal Outlet Septum during Cardiac Development.
Muscularization of the Mesenchymal Outlet Septum during Cardiac Development.
复制标题
心脏发育过程中间充质出口隔的肌肉化。
DOI：
10.3390/jcdd7040051
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发表时间：
2020-11-04
影响因子：
2.4
通讯作者：
Wessels A
中科院分区：
文献类型：
--
作者：
van den Hoff MJB;Wessels A
线状心管形成后，通过分离过程分为左右两部分。在这一过程的较晚阶段，在发育中的流出道内，最初的间充质出口间隔由于心肌化而变得肌肉化。心肌化被定义为现有心肌细胞向侧翼间质迁移的过程。使用转基因小鼠以及使用体外模型的实验方法的研究表明，Wnt和TGFβ信号在心肌化的调节中发挥重要作用。它们还显示了心肌细胞、心内膜源性细胞、神经嵴细胞和细胞外基质之间相互作用的重要性。有趣的是，wnt介导的非典型平面细胞极性信号被发现是出口间隔心肌化的关键调节因子，而wnt介导的典型β-连环蛋白信号是流出道缓冲层间充质细胞扩张的重要调节因子。
After the formation of the linear heart tube, it becomes divided into right and left components by the process of septation. Relatively late during this process, within the developing outflow tract, the initially mesenchymal outlet septum becomes muscularized as the result of myocardialization. Myocardialization is defined as the process in which existing cardiomyocytes migrate into flanking mesenchyme. Studies using genetically modified mice, as well as experimental approaches using in vitro models, demonstrate that Wnt and TGFβ signaling play an essential role in the regulation of myocardialization. They also show the significance of the interaction between cardiomyocytes, endocardial derived cells, neural crest cells, and the extracellular matrix. Interestingly, Wnt-mediated non-canonical planar cell polarity signaling was found to be a crucial regulator of myocardialization in the outlet septum and Wnt-mediated canonical β-catenin signaling is an essential regulator of the expansion of mesenchymal cells populating the outflow tract cushions.
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影响因子：
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通讯作者：
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