Corticotropin-releasing factor receptors in the dorsal raphe nucleus modulate social behavior in Syrian hamsters
Corticotropin-releasing factor receptors in the dorsal raphe nucleus modulate social behavior in Syrian hamsters
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DOI：
10.1007/s00213-007-0849-1
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发表时间：
2007-10-01
影响因子：
3.4
通讯作者：
Huhman, Kim L.
中科院分区：
文献类型：
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作者：
Cooper, Matthew A.;Huhman, Kim L.
在叙利亚仓鼠（Mesocricetus auratus），社会失败产生了长期的变化，随后的竞争行为称为条件性失败。这种压力引起的行为变化的特点是对一个新的、非攻击性的对手的顺从和防御行为增加，以及完全丧失正常的领土攻击性。促肾上腺皮质激素释放因子（Corticotropin-releasing factor，CRF）可影响中缝背核（dorsal raphe nucleus，DRN）内的肾上腺素能神经元，并通过CRF Ⅱ型受体（CRF-R2）调节习得性无助。（实验1：在200 nl盐水中的250或500 ng D-Phe CRF），或选择性CRF-R2拮抗剂（实验2：在200 nl盐水中的500 ng抗Svg-30），注射到DRN中将减少雄性仓鼠中条件性失败的获得。我们还测试了类似的假设条件性失败的表达（实验3和4）。结果输注D-Phe CRF到DRN显着降低了收购和表达的条件性失败相比，车辆控制，而抗Svg-30到DRN输注减少表达，但不收购。特别是，CRF拮抗DRN减少逃离新的对手，但没有恢复正常的领土侵略后，社会defeat.Conclusions我们的研究结果表明，增加飞行与条件性失败调制CRF-R2激活DRN内。总的来说，社交失败是一种行为学相关的压力源，似乎激活了至少一些与控制习得性无助有关的相同的神经基质。
Rationale In Syrian hamsters (Mesocricetus auratus), social defeat produces a prolonged change in subsequent agonistic behavior termed conditioned defeat. This stress-induced change in behavior is marked by increased submissive and defensive behavior toward a novel, nonaggressive opponent and a complete loss of normal territorial aggression. Corticotropin-releasing factor (CRF) has been shown to affect serotonergic neurons in the dorsal raphe nucleus (DRN) and to modulate learned helplessness via a CRF type-2 receptor (CRF-R2) mechanism.Objectives In this study, we tested the hypothesis that a nonselective CRF receptor antagonist (experiment 1: 250 or 500 ng D-Phe CRF in 200 nl saline), or a selective CRF-R2 antagonist (experiment 2: 500 ng anti-Svg-30 in 200 nl saline), injected into the DRN would reduce the acquisition of conditioned defeat in male hamsters. We also tested similar hypotheses for the expression of conditioned defeat (experiments 3 and 4).Results Infusion of D-Phe CRF into the DRN significantly reduced both the acquisition and expression of conditioned defeat compared to vehicle controls, whereas infusion of anti-Svg-30 into the DRN reduced expression but not acquisition. In particular, CRF antagonism in the DRN decreased fleeing from novel opponents but did not reinstate normal territorial aggression after social defeat.Conclusions Our results suggest that the increased flight associated with conditioned defeat is modulated by CRF-R2 activation within the DRN. Overall, social defeat is an ethologically relevant stressor that appears to activate at least some of the same neural substrates that have been implicated in the control of learned helplessness.