Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
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DOI：
10.1359/jbmr.060309
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发表时间：
2006-06-01
影响因子：
6.2
通讯作者：
Hughes-Fulford, Millie
中科院分区：
文献类型：
--
作者：
Li, Chai-Fei;Hughes-Fulford, Millie
十五分钟的生理MS诱导成骨细胞中的FGF-2。在这里，我们表明MS诱导MC 3 T3-E1和BMOp细胞从Fgf 2（+/+）小鼠分离的增殖; Fgf 2（-/-）BMOp细胞需要外源性FGF-2的正常增殖反应。fgf-2的诱导由PKA和ERK途径介导。
Fifteen minutes of physiological MS induces FGF-2 in osteogenic cells. Here, we show that MS induced proliferation in both MC3T3-E1 and BMOp cells isolated from Fgf2(+/+) mice; Fgf2(-/-) BMOp cells required exogenous FGF-2 for a normal proliferation response. The induction of fgf-2 is mediated by PKA and ERK pathways.