Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.
Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.
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神经元种群使用短期反馈机制的可变组合来稳定发射率。
DOI：
10.1371/journal.pbio.3001971
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发表时间：
2023-01
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
--
作者：
神经元严格调节放电频率，如果不这样做，会导致多种神经系统疾病。因此，神经科学中的一个基本问题是神经元如何在几十年内产生可靠的活动模式来产生行为。神经元具有内置的反馈机制，使它们能够监控其输出并快速稳定放电率。大多数工作强调的作用，一个占主导地位的反馈系统内的神经元群体的控制时刻到时刻的发射。相比之下，我们发现呼吸运动神经元使用2个活动依赖性控制器在跨细胞的独特组合，动态激活的Na+泵亚型，Kv 7通道的快速增强。这两种系统通过在动作电位爆发后降低兴奋性长达一分钟来限制放电率，但通过与活动相关的不同细胞信号、增加的细胞内Na+（Na+泵）和膜去极化（Kv 7通道）来募集。单个神经元并不简单地包含等量的每个系统。相反，神经元强控制下的Na+泵弱调节Kv 7增强，反之亦然沿着一个连续。因此，每个运动神经元通过Na+泵和Kv 7通道的独特组合保持其特征性放电率，所述Na+泵和Kv 7通道由不同的反馈信号动态调节。这些结果揭示了一种新的组织策略，稳定的电路输出涉及多个快速活动传感器成反比的神经元群体。神经元严格调节放电频率，如果不这样做，会导致多种神经系统疾病;这是如何做到的？呼吸运动神经元的这项研究表明，神经元群体使用两种活性调节剂（Na+泵和Kv 7通道）的独特组合，监测不同的放电率读数，以维持神经元输出。
Neurons tightly regulate firing rate and a failure to do so leads to multiple neurological disorders. Therefore, a fundamental question in neuroscience is how neurons produce reliable activity patterns for decades to generate behavior. Neurons have built-in feedback mechanisms that allow them to monitor their output and rapidly stabilize firing rate. Most work emphasizes the role of a dominant feedback system within a neuronal population for the control of moment-to-moment firing. In contrast, we find that respiratory motoneurons use 2 activity-dependent controllers in unique combinations across cells, dynamic activation of an Na+ pump subtype, and rapid potentiation of Kv7 channels. Both systems constrain firing rate by reducing excitability for up to a minute after a burst of action potentials but are recruited by different cellular signals associated with activity, increased intracellular Na+ (the Na+ pump), and membrane depolarization (Kv7 channels). Individual neurons do not simply contain equal amounts of each system. Rather, neurons under strong control of the Na+ pump are weakly regulated by Kv7 enhancement and vice versa along a continuum. Thus, each motoneuron maintains its characteristic firing rate through a unique combination of the Na+ pump and Kv7 channels, which are dynamically regulated by distinct feedback signals. These results reveal a new organizing strategy for stable circuit output involving multiple fast activity sensors scaled inversely across a neuronal population. Neurons tightly regulate firing rate, and a failure to do so leads to multiple neurological disorders; how is this done? This study of respiratory motoneurons shows that populations of neurons use unique combinations of two activity regulators (Na+ pumps and Kv7 channels) that monitor different readouts of firing rate to maintain neuronal output.
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影响因子：
46.9
作者：
Fuzik J;Zeisel A;Máté Z;Calvigioni D;Yanagawa Y;Szabó G;Linnarsson S;Harkany T
通讯作者：
Harkany T
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8.8
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Müller M
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64.8
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Davis GW
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Bayliss DA
影响因子：
64.5
作者：
Li, Boxing;Suutari, Benjamin S.;Sun, Simon(e) D.;Luo, Zhengyi;Wei, Chuanchuan;Chenouard, Nicolas;Mandelberg, Nataniel J.;Zhang, Guoan;Wamsley, Brie;Tian, Guoling;Sanchez, Sandrine;You, Sikun;Huang, Lianyan;Neubert, Thomas A.;Fishell, Gordon;Tsien, Richard W.
通讯作者：
Tsien, Richard W.