MOLECULAR APPROACH TO IDENTIFYING ROUTE OF TRANSMISSION OF TUBERCULOSIS IN THE COMMUNITY
MOLECULAR APPROACH TO IDENTIFYING ROUTE OF TRANSMISSION OF TUBERCULOSIS IN THE COMMUNITY
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DOI：
10.1016/0140-6736(93)92698-s
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发表时间：
1993-10-02
期刊：
影响因子：
168.9
通讯作者：
BODMER, T
中科院分区：
文献类型：
--
作者：
GENEWEIN, A;TELENTI, A;BODMER, T
人们越来越担心肺结核在欧洲的传播方式与在美国一样。我们使用DNA“指纹”技术对我们社区报告的结核病病例进行系统评价，以发现传播病灶。使用IS 6110探针对伯尔尼州1991-92年报告的经培养确诊的结核病病例（163例患者）的所有分离株进行检测。总共有45例患者（27.6%），可能与限制性片段长度多态性的基础上，进行了调查edepiphologically。最大的一组（n = 22）包括一个确定的社会群体的成员（吸毒者，无家可归者，酗酒者），结核病从他们传播到一般人群。在监测期间，一名关键患者出现耐多药结核病。这项人口研究表明：（i）结核分枝杆菌目前在欧洲广泛传播，其社会环境与美国相同;（ii）结核分枝杆菌确实“外溢"到一般人口;（iii）由于传播网络的复杂性，日常公共卫生服务活动难以识别问题的严重程度;和（iv）耐多药结核病在这种情况下发展。
There is growing concern that tuberculosis is spread in Europe in the way that it is in the USA. We have used DNA ''fingerprinting'' in a systematic evaluation of tuberculosis cases notified in our community to uncover foci of transmission.An IS6110 probe was used to test all isolates from culture-confirmed tuberculosis cases (163 patients) notified in 1991-92 in the Canton of Berne. In total, 45 patients (27.6%), potentially linked on the basis of restriction fragment length polymorphism, were investigated edepidemiologically. The largest group (n = 22) included members of a defined social group (drug addicts, homeless persons, alcoholics), from whom tuberculosis spread to the general population. A key patient developed multidrug-resistant tuberculosis during the surveillance period.This population study showed that (i) extensive transmission of Mycobacterium tuberculosis is now taking place in Europe in the same social setting as in the USA; (ii) there is definite ''spillover'' to the general population; (iii) the dimensions of the problem cannot be recognised easily by routine public health service activities because of the complexity of the transmission network; and (iv) multidrug-resistant tuberculosis develops in this setting.