Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer
Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer
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DOI：
10.1016/s1010-5182(98)80020-6
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发表时间：
1998-08-01
影响因子：
3.1
通讯作者：
Schwenzer, N
中科院分区：
文献类型：
--
作者：
Krimmel, M;Hoffmann, J;Schwenzer, N
口腔癌复发或淋巴结转移者预后有限，继发于手术和放疗；解剖结构经常发生严重改变，使得通过临床和放射学检查对肿瘤重新生长进行早期诊断变得困难。我们研究了 121 名未经治疗的头颈鳞状细胞癌 (SCCHN) 患者治疗前后血清 SCC-Ag、CEA、CA 19.9 和 CA 125 的变化情况，并评估了它们与口腔癌诊断和随访的相关性。 C4 19.9 和 CA 125 似乎对这种肿瘤实体没有用处，CEA 更类似于受检查患者的饮酒和吸烟习惯，而不是他们的疾病状态。只有 SCC-Ag 与肿瘤负荷相关并代表病程。如果复发，一半患者的 SCC-Ag 在诊断前 1-2 个月呈指数增加。
The prognosis of oral cavity carcinoma is limited ba recurrent disease or lymph node metastasis, Secondary to surgery and radiotherapy; anatomical structures are often severly changed and make early diagnosis of renewed tumour growth by clinical and radiological examination difficult. We studied the course of serum SCC-Ag, CEA, CA 19.9 and CA 125 in 121 patients with untreated squamous cell carcinoma of the head and neck (SCCHN) before and after therapy and evaluated their relevance for diagnosis and follow-up in oral cancer. C4 19.9 and CA 125 seemed to be useless for this tumour entity, CEA resembled more the alcohol consumption and smoking habits of the patients examined than their state of disease. Only SCC-Ag correlated with the tumour burden and represented the disease course. In the event of relapse, half the patients had an exponential increase in SCC-Ag, 1-2 months prior to diagnosis.