ORAL (N-3) FATTY-ACID SUPPLEMENTATION SUPPRESSES CYTOKINE PRODUCTION AND LYMPHOCYTE-PROLIFERATION - COMPARISON BETWEEN YOUNG AND OLDER WOMEN
ORAL (N-3) FATTY-ACID SUPPLEMENTATION SUPPRESSES CYTOKINE PRODUCTION AND LYMPHOCYTE-PROLIFERATION - COMPARISON BETWEEN YOUNG AND OLDER WOMEN
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DOI：
10.1093/jn/121.4.547
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发表时间：
1991-04-01
影响因子：
4.2
通讯作者：
GORBACH, SL
中科院分区：
文献类型：
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作者：
MEYDANI, SN;ENDRES, S;GORBACH, SL
在年轻（23-33岁）和老年（51-68岁）妇女中研究了（n-3）脂肪酸补充对细胞因子产生和淋巴细胞增殖的影响。 受试者每天补充2.4 g（n-3）脂肪酸，持续3个月。 在补充之前和之后1、2和3个月收集血液。 补充（n-3）脂肪酸使年轻女性的总白细胞介素（IL）-1-β合成减少了48%，但老年女性减少了90%;肿瘤坏死因子在年轻女性中减少了58%，老年女性减少了70%。 白细胞介素-6在年轻女性中减少了30%，但在老年女性中减少了60%。 老年妇女产生较少的IL-2和植物血凝素（PHA）的促有丝分裂反应比年轻妇女之前（n-3）脂肪酸补充剂。 （n-3）脂肪酸补充剂减少了两组中IL-2的产生;然而，这种减少仅在老年妇女中显着。 PHA刺激的促有丝分裂反应显着降低（n-3）脂肪酸在老年妇女（36%）。 因此，长期（n-3）脂肪酸补充剂减少了年轻女性的细胞因子产生和老年女性的细胞因子产生和T细胞有丝分裂。 老年妇女的减少幅度比年轻妇女更大。 尽管（n-3）脂肪酸诱导的细胞因子产生减少可能具有有益的抗炎作用，但其对老年妇女IL-2产生和淋巴细胞增殖的抑制可能不理想。
The effect of (n-3) fatty acid supplementation on cytokine production and lymphocyte proliferation was investigated in young (23-33 y) and older (51-68 y) women. Subjects supplemented their diets with 2.4 g of (n-3) fatty acid/d for 3 mo. Blood was collected before and after 1, 2 and 3 mo of supplementation. The (n-3) fatty acid supplementation reduced total interleukin (IL)-1-beta synthesis by 48% in young women but by 90% in older women; tumor necrosis factor was reduced by 58% in young and 70% in older women. Interleukin-6 was reduced in young women by 30% but by 60% in older women. Older women produced less IL-2 and had lower mitogenic responses to phytohemagglutinin (PHA) than young women prior to (n-3) fatty acid supplementation. The (n-3) fatty acid supplementation reduced IL-2 production in both groups; however, this reduction was significant only in older women. The PHA-stimulated mitogenic response was significantly reduced by (n-3) fatty acid in older women (36%). Thus, long-term (n-3) fatty acid supplementation reduced cytokine production in young women and cytokine production and T cell mitogenesis in older women. The reduction was more dramatic in older women than in young women. Although (n-3) fatty acid-induced reduction in cytokine production may have beneficial anti-inflammatory effects, its suppression of IL-2 production and lymphocyte proliferation in older women may not be desirable.