THE EFFECT OF GLUCO CORTICO STEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES
THE EFFECT OF GLUCO CORTICO STEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES
复制标题
DOI：
10.1084/jem.131.3.429
复制
发表时间：
1970-01-01
影响因子：
15.3
通讯作者：
VAN FURTH R
中科院分区：
文献类型：
--
作者：
THOMPSON J;VAN FURTH R
糖皮质激素对单核吞噬细胞动力学的影响，即，外周血单核细胞和腹膜巨噬细胞，在正常小鼠以及在腹膜腔中诱发炎症反应的小鼠中进行研究。糖皮质激素的给药导致循环单核细胞数量快速减少（3-6小时内），持续时间取决于化合物的性质和剂量。水溶性地塞米松磷酸钠仅具有短暂活性（小于12小时），但形成皮下储库的醋酸氢化可的松可减少单核细胞数量超过2周。在正常小鼠中，氢化可的松不影响已经存在于腹腔中的巨噬细胞的数量，但单核吞噬细胞从循环进入腹腔的转运被阻止。在腹膜腔的炎症反应期间，氢化可的松抑制外周血中单核细胞数量的增加和腹膜巨噬细胞数量的增加。炎性渗出物的减少似乎是由于外周血单核吞噬细胞流入减少所致。糖皮质激素对单核吞噬细胞无溶解作用。
The effect of glucocorticosteroids on the kinetics of mononuclear phagocytes, i.e., peripheral blood monocytes and peritoneal macrophages, was studied in normal mice, as well as in mice in which an inflammatory reaction was evoked in the peritoneal cavity. The administration of glucocorticosteroids resulted in a rapid decrease (within 3–6 hr) in the number of circulating monocytes, the duration being dependent on the nature and dose of the compound. The water-soluble dexamethasone sodium phosphate is only briefly active (less than 12 hr), but hydrocortisone acetate, which forms a subcutaneous depot, reduced the number of monocytes for more than 2 wk. In normal mice, hydrocortisone did not affect the number of macrophages already present in the peritoneal cavity, but the transit of mononuclear phagocytes from the circulation into the peritoneal cavity was arrested. During an inflammatory response in the peritoneal cavity, hydrocortisone suppresses both the increase in the number of monocytes in the peripheral blood and the increase in the number of peritoneal macrophages. This reduction of the inflammatory exudate appeared to be due to a diminished influx of mononuclear phagocytes from the peripheral blood. No lytic action of glucocorticosteroids on the mononuclear phagocytes could be demonstrated.