An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis
An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis
复制标题
氢键催化对映体选择性合成苯并轴向手性吲哚
DOI：
10.1021/acs.orglett.9b01828
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Xu Peng Fei
中科院分区：
文献类型：
--
作者：
Liu Jin Yu;Yang Xie Chao;Liu Zhen;Luo Yong Chun;Lu Hong;Gu Yu Cheng;Fang Ran;Xu Peng Fei
通过不对称氢键给体催化构建轴手性吲哚，以高产率和良好的对映选择性合成了一系列轴手性联芳二醇。此外，新的轴向手性化合物被证明是一种有效和实用的不对称催化剂。该方法不仅为合成轴向手性化合物提供了一种新的方法，而且拓展了手性催化剂的应用范围。
A variety of axially chiral biaryldiols were synthesized in good yields with excellent atropo-enantioselectivities through construction of axially chiral indoles catalyzed by asymmetric hydrogen-bond donors. In addition, the new axially chiral compounds were proved to be efficient and practical catalysts for asymmetric catalysis. The strategy not only provides a novel method to synthesize axially chiral compounds but also extends the scope of chiral catalysts.