10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.
10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.
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DOI：
10.1155/2015/425261
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发表时间：
2015
影响因子：
4.7
通讯作者：
Honda S
中科院分区：
文献类型：
--
作者：
Honda Y;Araki Y;Hata T;Ichihara K;Ito M;Tanaka M;Honda S
据报道，蜜蜂产生的皇家浆（RJ）具有多种有益健康的特性，并被认为对不同物种以及蜜蜂具有长寿功能。10-羟基-2-癸烯酸（10-HDA），由蜜蜂产生的RJ的主要脂质成分，以前被证明可以增加秀丽隐杆线虫的寿命。本研究的目的是阐明参与10-HDA延长寿命的信号通路。10-HDA进一步延长了daf-2突变体的寿命，daf-2突变体通过减少胰岛素样信号传导（ILS）而表现出长寿命，这表明10-HDA延长了寿命而不依赖于ILS。另一方面，10-HDA没有延长eat-2突变体的寿命，这些突变体通过食物摄入缺陷引起的饮食限制显示出长寿命。这一发现表明，10-HDA通过饮食限制信号延长寿命。我们进一步发现，10-HDA没有延长daf-15中长寿突变体的寿命，daf-15编码Raptor，Raptor是雷帕霉素（TOR）组分的靶标，表明10-HDA与TOR信号传导共享一些长寿控制机制。此外，发现10-HDA赋予对热和氧化应激的耐受性。10-HDA不是通过ILS而是通过饮食限制和C.优雅
Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.