LONG-TERM POTENTIATION IS LOST IN AGED RATS BUT PRESERVED BY CALORIE RESTRICTION
LONG-TERM POTENTIATION IS LOST IN AGED RATS BUT PRESERVED BY CALORIE RESTRICTION
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DOI：
10.1097/00001756-199212000-00013
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发表时间：
1992-12-01
期刊：
影响因子：
1.7
通讯作者：
CARPENTER, DO
中科院分区：
文献类型：
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作者：
HORI, N;HIROTSU, I;CARPENTER, DO
突触群体反应、强直后增强 (PTP) 和长时程增强 (LTP) 的记录是在约 2 个月和 24 个月大的随意喂养的大鼠的海马切片中的 CA1 区进行的，以及在约 24 个月大的动物中进行的，这些动物自断奶以来热量摄入被限制为对照动物的 60%。老的自由活动动物的 PTP 和 LTP 均大大降低。大约 24 个月大时热量限制的大鼠表现出海马反应，其初始峰值幅度更类似于 2 个月龄对照组的海马反应，而不是 24 个月时自由活动的动物。这些观察结果表明，热量限制可以保护神经系统功能，包括 LTP 等可塑性指标，否则这些功能会随着衰老而丧失。
RECORDINGS of synaptic population responses, post-tetanic potentiation (PTP) and long-term potentiation (LTP) were made from area CA1 in hippocampal slices from ad libitum-fed rats at about 2 and 24 months of age, and also in animals at about 24 months of age that had been restricted to 60% of the caloric intake of control animals since weaning. Both PTP and LTP were greatly reduced in the old ad-lib animals. Calorically-restricted rats at about 24 months of age showed hippocampal responses with initial peak amplitudes more like those of 2-month controls than the ad-lib animals at 24 months. These observations suggest that calorie restriction preserves nervous-system functions, including indicators of plasticity such as LTP, which are otherwise lost in aging.