Genome Stability Requires p53
Genome Stability Requires p53
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DOI：
10.1101/cshperspect.a026096
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发表时间：
2016-06-01
影响因子：
5.4
通讯作者：
Eischen, Christine M.
中科院分区：
文献类型：
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作者：
Eischen, Christine M.
现在很清楚，功能性p53对于保护基因组免受导致肿瘤发生的改变至关重要。然而，由于与p53激活相关的细胞应激和途径众多，关于p53如何维持基因组稳定性和所涉及的蛋白质仍有许多未知之处。目前的理解的多种方式p53有助于基因组的稳定性，以及如何两个负调控，Mdm2和Mdmx，诱导基因组的不稳定性将被描述。
It is now clear that functional p53 is critical to protect the genome from alterations that lead to tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 activation, much remains unknown about how p53 maintains genome stability and the proteins involved. The current understanding of the multiple ways p53 contributes to genome stability and how two of its negative regulators, Mdm2 and Mdmx, induce genome instability will be described.