INCREASED UREAGENESIS AND IMPAIRED NITROGEN USE DURING INFUSION OF A SYNTHETIC AMINO-ACID FORMULA - A CONTROLLED TRIAL
INCREASED UREAGENESIS AND IMPAIRED NITROGEN USE DURING INFUSION OF A SYNTHETIC AMINO-ACID FORMULA - A CONTROLLED TRIAL
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DOI：
10.1056/nejm198204293061702
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
HEYMSFIELD, SB
中科院分区：
文献类型：
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作者：
SMITH, JL;ARTEAGA, C;HEYMSFIELD, SB
在一项评估高氮Vivonex生物学价值的对照试验中，研究人员在8天的平衡期内将高氮Vivonex元素日粮与预消化蛋白产品MJ7041和固体食物进行了比较。通过测量氮和能量的表观吸收、氮平衡、血尿素氮和尿尿素氮，对3例吸收不良患者和1例无吸收不良患者的各配方进行评价。Vivonex的净肠吸收倾向于更高，但并非所有患者都如此。3种日粮的氮平衡差异一致；固体食物组和MJ7041组吸收N的滞留量分别是Vivonex组的9倍和16倍。每隔一段Vivonex期的开始都会导致尿素氮迅速增加，但这一趋势很快被替代日粮逆转。虽然高氮Vivonex对氮素利用损害的机制尚不清楚，但其低生物学价值和易引起氮血症的倾向应铭记于心。
In a controlled trial conducted to assess the biologic value of High Nitrogen Vivonex, this elemental diet was compared with predigested protein, Product MJ7041, and with solid food during 8-day balance periods. Each formula was evaluated in 3 patients with malabsorption and one without it, by measuring apparent absorption of N and energy, N balance, and blood and urinary urea N. Overall energy and N absorption in the patients with malabsorption was better with either special diet than with solid food; net intestinal uptake of Vivonex tended to be higher but not consistently so in all patients. Nitrogen balance differed consistently during the 3 diets; with solid food and MJ7041, retention of absorbed N was respectively, 9 and 16 times greater than with Vivonex. Institution of each Vivonex period led to a prompt increase in urea nitrogen, a trend quickly reversed by the alternative diets. Although the mechanism for the impairment of N use caused by High Nitrogen Vivonex is unknown, its low biologic value and tendency to cause azotemia should be kept in mind.