Correlations and dissociations between BOLD signal and P300 amplitude in an auditory, oddball task: a parametric approach to combining fMRI and ERP
Correlations and dissociations between BOLD signal and P300 amplitude in an auditory, oddball task: a parametric approach to combining fMRI and ERP
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DOI：
10.1016/s0730-725x(02)00496-4
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发表时间：
2002-05-01
影响因子：
2.5
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Horovitz, SG;Skudlarski, P;Gore, JC
提出一种参数方法来检验在听觉oddball范式期间，用事件相关电位（ERPs）测量的神经元活动与用功能性磁共振成像（fMRI）观察到的血液动力学反应之间的关系。在验证诱发反应P300的振幅随着oddball目标呈现概率降低而增加之后，我们探究了目标频率对fMRI信号的相应影响。我们预测并证实，一些在每次oddball之后显示激活变化的区域受oddball呈现率或oddball目标概率的影响。我们假定那些随着概率降低激活增加的区域可能负责P300振幅的相应变化。与P300波振幅相关的fMRI区域是缘上回、丘脑、脑岛和右侧内侧额叶回，并且可能是P300波的源。其他区域，例如前扣带回皮质和后扣带回皮质，在oddball范式期间被激活，但它们的fMRI信号变化与P300振幅不相关。因此，这项研究表明在参数设计中结合fMRI和ERP如何识别与任务相关的活动源，并能够区分具有不同反应特性的区域。（C）2002爱思唯尔科学公司。保留所有权利。
A parametric method is proposed to examine the relationship between neuronal activity, measured with event related potentials (ERPs), and the hemodynamic response, observed with functional magnetic resonance imaging (fMRI), during an auditory oddball paradigm. After verifying that the amplitude of the evoked response P300 increases as the probability of oddball target presentation decreases, we explored the corresponding effect of target frequency on the fMRI signal. We predicted and confirmed that some regions that showed activation changes following each oddball are affected by the rate of presentation of the oddballs, or the probability of an oddball target. We postulated that those regions that increased activation with decreasing probability might be responsible for the corresponding changes in the P300 amplitude.fMRI regions that correlated with the amplitude of the P300 wave were supramarginal gyri, thalamus, insula and right medial frontal gyrus, and are presumably sources of the P300 wave. Other regions, such as anterior and posterior cingulate cortex, were activated during the oddball paradigm but their fMRI signal changes were not correlated with the P300 amplitudes. This study thus shows how combining fMRI and ERP in a parametric design identifies task-relevant sources of activity and allows separation of regions that have different response properties. (C) 2002 Elsevier Science Inc. All rights reserved.