Diabetes mellitus and risk of endometrial cancer: a meta-analysis
Diabetes mellitus and risk of endometrial cancer: a meta-analysis
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DOI：
10.1007/s00125-007-0681-5
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发表时间：
2007-07-01
期刊：
影响因子：
8.2
通讯作者：
Wolk, A.
中科院分区：
文献类型：
--
作者：
Friberg, E.;Orsini, N.;Wolk, A.
目的/假设在大多数（但不是全部）研究中，糖尿病与子宫内膜癌风险显著增加有关。为了定量评估糖尿病与子宫内膜癌风险之间的关系，我们对病例对照研究和队列研究进行了荟萃分析。研究对象和方法我们通过检索PubMed和Embase到2007年1月的文献以及检索相关文章的参考文献列表来确定研究。采用随机效应模型计算95% ci的总相对危险度（rr）。结果糖尿病（主要是2型）和子宫内膜癌的分析基于16项研究（3项队列研究和13项病例对照研究），包括96003名参与者和7596例子宫内膜癌。其中12项研究显示，统计上显著增加了患子宫内膜癌的风险，4项研究没有显著增加患子宫内膜癌的风险。在我们的荟萃分析中，我们发现糖尿病与子宫内膜癌风险增加有统计学意义上的显著相关（总RR 2.10, 95% CI 1.75-2.53）。病例对照的风险估计（RR 2.22, 95% CI 1.80-2.74）略高于队列研究（RR 1.62, 95% CI 1.21-2.16），仅调整年龄的研究（RR 2.74, 95% CI 1.87-4.00）强于多因素调整（RR 1.92, 95% CI 1.58-2.33），在美国进行的研究略低于在欧洲进行的研究。1型糖尿病与子宫内膜癌的分析基于三项研究，发现有统计学意义的正相关（总结RR 3.15, 95%CI 1.07-9.29）。荟萃分析的结果支持糖尿病与子宫内膜癌风险增加之间的关系。
Aims/hypothesis Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies.Subjects and methods We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model.Results The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29).Conclusions/interpretation Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer.