SUPPRESSION OF SHAM FEEDING BY INTRAINTESTINAL NUTRIENTS IS NOT CORRELATED WITH PLASMA CHOLECYSTOKININ ELEVATION
SUPPRESSION OF SHAM FEEDING BY INTRAINTESTINAL NUTRIENTS IS NOT CORRELATED WITH PLASMA CHOLECYSTOKININ ELEVATION
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DOI：
10.1152/ajpregu.1993.264.5.r972
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发表时间：
1993-05-01
影响因子：
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通讯作者：
RITTER, RC
中科院分区：
文献类型：
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作者：
BRENNER, L;YOX, DP;RITTER, RC
为了检测血液中胆囊收缩素（CCK）参与抑制大鼠肠道营养素对假摄食的可能性，我们检测了油酸、麦芽糖、L-苯丙氨酸（L-Phe）和酪蛋白抑制15%蔗糖溶液假摄食的能力。血浆CCK浓度在平行实验中测定，其中相同的肠道营养素注入大鼠没有喂养。肠内油酸抑制假喂养和升高血浆CCK浓度。酪蛋白输注产生的血浆CCK浓度与油酸酯产生的浓度相似，但不抑制假喂养。麦芽糖和L-Phe抑制假喂养，但未能显着提高血浆CCK。以前，我们表明，CCK受体拮抗剂减弱抑制假喂养的肠输液的油酸或麦芽糖，这表明内源性CCK参与抑制假喂养的一些肠道营养素。本文报道的研究结果表明，营养素输注后血浆CCK水平与假喂养抑制无关。因此，CCK参与营养抑制假喂养的机制可能不依赖于刺激诱导的血浆CCK升高。
To test the possibility that blood-borne cholecystokinin (CCK) participates in suppression of sham feeding by intestinal nutrients in rats, we examined the ability of oleate, maltose, L-phenylalanine (L-Phe), and casein to suppress sham ingestion of 15% sucrose solution. Plasma CCK concentrations were measured in parallel experiments in which the same intestinal nutrients were infused in rats that were not feeding. Intraintestinal oleate suppressed sham feeding and elevated plasma CCK concentrations. Casein infusion produced plasma CCK concentrations similar to those produced by oleate but did not suppress sham feeding. Both maltose and L-Phe suppressed sham feeding but failed to significantly elevate plasma CCK. Previously we demonstrated that CCK receptor antagonists attenuate suppression of sham feeding by intestinal infusion of either oleate or maltose, suggesting that endogenous CCK participates in suppression of sham feeding by some intestinal nutrients. The results of the study reported here suggest that plasma CCK levels after nutrient infusion are not correlated with suppression of sham feeding. Therefore, the mechanism of CCK's participation in nutrient-induced suppression of sham feeding may not depend on stimulus-induced elevation of plasma CCK.