Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development
Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development
复制标题
氯化镉诱导斑马鱼发育的跨代神经毒性
DOI：
10.1016/j.etap.2020.103545
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Yin Huancai
中科院分区：
文献类型：
--
作者：
Tian Jingjing;Hu Jia;Liu Di;Yin Jian;Chen Mingli;Zhou Lianqun;Yin Huancai
重金属镉作为一种重要的环境污染物，对生态环境的稳定和机体健康产生了重大的负面影响。先前的研究表明，氯化镉会损害神经、骨骼、内分泌和生殖系统，但据我们所知，镉对暴露动物后代的行为、神经递质水平和神经元发育的影响尚未见报道。本研究以性成熟的斑马鱼为研究对象，在不同浓度的氯化镉环境下暴露60 d，对F1后代的行为、神经递质水平、神经发育和神经递质代谢进行了研究。结果表明：亲代斑马鱼接触氯化镉后，F1后代游泳速度和游泳距离显著降低；神经递质的水平，如多巴胺、血清素和乙酰胆碱被破坏。神经发育和神经递质代谢相关基因表达模式发生改变，导致斑马鱼F1后代发育性神经毒性。这些发现进一步揭示了氯化镉对水生生态系统的危害。
As an important environmental pollutant, the heavy metal cadmium has a significant negative impact on the stability of the ecological environment and on organismal health. Previous studies have shown that cadmium chloride can damage the nervous, skeletal, endocrine, and reproductive systems, but to our knowledge, the effects of cadmium on the behavior, neurotransmitter levels, and neuronal development in the offspring of exposed animals have not been reported. In the present study, sexually-mature zebrafish were exposed to cadmium chloride at different concentrations for 60 days, and in this background, behavior, neurotransmitters level, neuro-development and neurotransmitter metabolism was investigated in the F1 offspring. The results showed that exposure of the parental zebrafish to cadmium chloride resulted swimming speed and distance of F1 offspring significantly reduced; the levels of neurotransmitters, such as dopamine, serotonin, and acetylcholine is disrupted. neuro-development and neurotransmitter metabolism related genes expression pattern was altered, which cause zebrafish F1 offspring developmental neurotoxicity. These findings provide further insights into the harm posed by cadmium chloride to the aquatic ecosystems.