HUMAN SERUM ACTIVITIES AGAINST HEMOPHILUS-INFLUENZAE, TYPE-B
HUMAN SERUM ACTIVITIES AGAINST HEMOPHILUS-INFLUENZAE, TYPE-B
复制标题
DOI：
10.1172/jci106793
复制
发表时间：
1972-01-01
影响因子：
15.9
通讯作者：
JOHNSTON, RB
中科院分区：
文献类型：
--
作者：
ANDERSON, P;SMITH, DH;JOHNSTON, RB
通过测定血清对b型流感嗜血杆菌的杀菌和调理活性以及使用多核糖磷酸（型特异性荚膜抗原）致敏的红细胞进行被动血凝活性，研究了正常成人对b型流感嗜血杆菌的体液免疫。在114份检测血清中，约60%可检测到血凝活性。血清杀菌和调理活性，发现在所有的血清测试，但在一些血清中的水平是相当低的。抗菌活性不仅是由于针对多核糖磷酸胶囊的抗体，而且还由于似乎是针对体细胞抗原的抗体。B型菌株对特定血清的抗体抗体的敏感性不同，但对抗囊抗体一致敏感。
Humoral immunity toHemophilus influenzae,type b was studied in normal human adults by means of assays for serum bactericidal and opsonizing activities against the organism and for passive hemagglutinating activity using erythrocytes sensitized with polyribophosphate, the type-specific capsular antigen. Hemagglutinating activity was detectable in about 60% of the 114 sera tested. Serum bactericidal and opsonizing activities were found in all sera tested; the levels in some sera, however, were quite low. The antibacterial activities were due not only to antibodies directed against the polyribophosphate capsule but also to antibodies that appear to be directed against somatic antigens. Type b strains differed in their susceptibility to the antisomatic antibodies of particular sera but were uniformly sensitive to anticapsular antibody.