Vasopressin exhibits a rhythmic daily pattern in cerebrospinal fluid but not in blood.
Vasopressin exhibits a rhythmic daily pattern in cerebrospinal fluid but not in blood.
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加压素在脑脊液中表现出有节律的每日模式，但在血液中则不然。
DOI：
10.1126/science.7268432
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Fisher,DA
中科院分区：
文献类型：
--
作者：
Reppert,SM;Artman,HG;Swaminathan,S;Fisher,DA
从自由放养的猫中连续抽取脑脊液中的加压素浓度的检查显示了一个大的每日节律，在白天出现高浓度。在循环中未检测到类似的肽每日模式。脑脊髓液中加压素的节律性波动进一步暗示了这种体液作为神经内分泌通讯的载体，并提供了加压素可能通过脑脊髓液调节行为过程（如记忆）的额外证据。
Examination of vasopressin concentrations in cerebrospinal fluid continuously withdrawn from free-ranging cats revealed a large daily rhythm, with high concentrations occurring during daylight hours. A similar daily pattern of the peptide was not detected in the circulation. The rhythmic fluctuation of vasopressin in the cerebrospinal fluid further implicates this body fluid as a vehicle of neuroendocrine communication and provides additional evidence that vasopressin may act by means of the cerebrospinal fluid to modulate behavioral processes, such as memory.