The stressed CNS: when glucocorticoids aggravate inflammation.
The stressed CNS: when glucocorticoids aggravate inflammation.
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DOI：
10.1016/j.neuron.2009.09.032
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发表时间：
2009-10-15
期刊：
影响因子：
16.2
通讯作者：
Sapolsky RM
中科院分区：
文献类型：
--
作者：
Sorrells SF;Caso JR;Munhoz CD;Sapolsky RM
糖皮质激素（GC）是在应激反应期间释放的激素，其免疫抑制和抗炎特性是众所周知的;然而，最近的进展已经发现了它们具有相反方向作用的情况。中枢神经系统是一个特别有趣的例子，这既是因为它独特的免疫环境，也是因为GC在不同的大脑区域影响不同的免疫反应。在这个角度来看，我们讨论的情况下，GC增加中枢神经系统炎症，并指出未来的研究方向。
Glucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite direction. The CNS is a particularly interesting example, both because of its unique immune environment, and because GCs affect immune responses differently in different brain regions. In this perspective we discuss the contexts wherein GCs increase CNS inflammation and point out directions for future investigation.