Bidirectional stimulation of the white-opaque transition of Candida albicans by ultraviolet irradiation.
Bidirectional stimulation of the white-opaque transition of Candida albicans by ultraviolet irradiation.
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DOI：
10.1099/00221287-135-5-1201
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发表时间：
1989-05
期刊：
影响因子：
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通讯作者：
Brian Morrow;Julia M. Anderson;Jane Wilson;D. Soll
中科院分区：
文献类型：
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作者：
Brian Morrow;Julia M. Anderson;Jane Wilson;D. Soll
大多数菌株的白色念珠菌能够自发切换和在一些表型之间的高频率可区分的菌落形态。白色念珠菌菌株WO-1在两种主要表型（“白色”和“不透明”）和一种次要表型（“模糊”）之间的切换频率在低剂量紫外线照射下急剧增加，导致不到20%的人口死亡。紫外线照射的影响在许多代中继续表现出来，被刺激的扇形证明了这一点。紫外线照射刺激了白色到不透明和不透明到白色方向的转换，表明一个共同的机制在两个方向上都起作用。
Most strains of Candida albicans are capable of switching spontaneously and at high frequency between a number of phenotypes distinguishable by colony morphology. The switching frequency of Candida albicans strain WO-1 between two predominant phenotypes, 'white' and 'opaque', and a minor phenotype, 'fuzzy', increased dramatically with low doses of ultraviolet irradiation that killed less than 20% of the population. The ultraviolet irradiation effect continued to be expressed over many generations as evidenced by stimulated sectoring. Ultraviolet irradiation stimulated switching in both the white-to-opaque and opaque-to-white direction, suggesting that a common mechanism functions in both directions.