Normative data for iliac bone histomorphometry in growing children
Normative data for iliac bone histomorphometry in growing children
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DOI：
10.1016/s8756-3282(99)00257-4
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发表时间：
2000-02-01
期刊：
影响因子：
4.1
通讯作者：
Parfitt, AM
中科院分区：
文献类型：
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作者：
Glorieux, FH;Travers, R;Parfitt, AM
只有通过骨组织形态计量学才能了解正常和病理性骨发育。然而，由于缺乏参考数据，这项技术在儿科的应用迄今为止受到阻碍。因此，我们从58名年龄在1.5岁至22.9岁之间的个体（25名男性; 48名受试者进行了四环素标记）中获得了贯穿髂骨样本，这些受试者因骨发育和代谢异常而接受了手术。松质骨参数和皮质骨宽度的组织形态计量学分析结果显示为5个年龄组的平均值和标准差以及中位数和范围。此外，原始数据可从作者处获得。皮质骨宽度和松质骨体积都有显著的年龄依赖性增加，后者是由于骨小梁厚度增加所致。类骨质厚度随年龄变化不明显，骨表面骨形成指标随年龄增长呈下降趋势，反映了类似的激活频率变化，矿物质沉积率随年龄持续下降。不同年龄组的骨吸收参数无显著差异。从相邻的网站，在8个科目获得的配对活检，被用来检查组织形态计量学参数在儿童的再现性。最低变异系数（
Many insights into normal and pathologic bone development can only be gained by bone histomorphometry. However, the use of this technique in pediatrics has so far been hampered by the lack of reference data. Therefore, we obtained transfixing iliac bone samples from 58 individuals between 1.5 and 22.9 years of age (25 male; tetracycline labeling performed in 48 subjects), who underwent surgery for reasons independent of abnormalities in bone development and metabolism. The results of histomorphometric analyses of cancellous parameters and cortical width are presented as means and standard deviations, as well as medians and ranges in five age groups. In addition, the original data are available from the authors. There were significant age-dependent increases in both cortical width and cancellous bone volume, the latter being due to an increase in trabecular thickness. Osteoid thickness did not vary significantly with age, Bone surface-based indicators of bone formation showed an age-dependent decline, reflecting similar changes in activation frequency, Mineral apposition rate decreased continuously with age. Parameters of bone resorption did not vary significantly between age groups. Paired biopsies from adjacent sites, obtained in eight subjects, were used to examine the reproducibility of histomorphometric parameters in children. The lowest coefficients of variation (