BLOOD-VISCOSITY IN SMALL TUBES - EFFECT OF SHEAR RATE, AGGREGATION, AND SEDIMENTATION
BLOOD-VISCOSITY IN SMALL TUBES - EFFECT OF SHEAR RATE, AGGREGATION, AND SEDIMENTATION
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DOI：
10.1152/ajpheart.1987.253.3.h540
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发表时间：
1987-09-01
影响因子：
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通讯作者：
JOHNSON, PC
中科院分区：
文献类型：
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作者：
REINKE, W;GAEHTGENS, P;JOHNSON, PC
在垂直玻璃管(ID 30.2-132.3μm)中测定表观粘度，其中含有人红细胞悬浮液，其中A)血清，B)含有0.5g/100ml白蛋白的盐水，C)血浆，和D)含有葡聚糖250的血浆，进料血细胞比容为0.45。压力-流量关系是在 0.15 至 250 s-1 之间的伪剪切率 (.hivin.u) 范围内获得的。发现非聚集悬浮液（A和B）中的相对粘度随着.hivin.u的降低而单调增加。 Fahraeus-Lindqvist 效应存在于 .hivin.u 的整个范围内。在两种聚集悬浮液（C和D）中，粘度最初在较大但不是较小的管中增加，同时.hivin.u下降，并且在所有管中在某些特征.hivin.u（通常低于10 s-1）处下降。在较大的管中和在具有较大聚集倾向的悬浮液中，粘度降低得较大。使用悬浮液 D，在最低剪切速率范围内消除了 Fahraeus-Lindqvist 效应。随着粘度下降，无细胞边缘区的宽度增加（最大为管半径的40%）。还使用安装在水平位置的管中的悬浮液C进行粘度和无细胞边缘区的测量。与垂直管相反，发现粘度随着.hivin.u的减少而单调增加，这与仅在管的上部部分中的细胞沉降和无细胞层的发育相关。
Apparent viscosity was determined in vertical glass tubes (ID 30.2-132.3 .mu.m) with suspensions of human red cells in A) serum, B) saline containing 0.5 g/100 ml albumin, C) plasma, and D) plasma containing Dextran 250 at a feed hematocrit of 0.45. Pressure-flow relationships were obtained in a range of pseudo-shear rates (.hivin.u) between 0.15 and 250 s-1. Relative viscosities in the nonaggregating suspensions (A and B) were found to increase monotonically with decreasing .hivin.u. The Fahraeus-Lindqvist effect was present in the entire range of .hivin.u. In the two aggregating suspensions (C and D), viscosities increased initially in larger but not small tubes with declining .hivin.u and fell in all tubes at some characteristic .hivin.u (usually below 10 s-1). Viscosity reduction was greater in the larger tubes and in suspensions with greater aggregation tendency. With suspension D, the Fahraeus-Lindqvist effect was eliminated in the lowermost shear-rate range. The cell-free marginal zone increased in width (to a maximum of .apprx. 40% of tube radius) as viscosity declined. Measurements of viscosity and cell-free marginal zone were also performed with suspension C in tubes mounted in horizontal position. In contrast to vertical tubes, a monotonic increase in viscosity was found with decreasing .hivin.u, associated with cell sedimentation and development of a cell-free layer only in the upper portion of the tubes.