Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography
Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography
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DOI：
10.1002/nbm.1189
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发表时间：
2008-03-01
影响因子：
2.9
通讯作者：
Braun, Juergen
中科院分区：
文献类型：
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作者：
Sack, Ingolf;Beierbach, Bernd;Braun, Juergen
本工作的目的是发展磁共振弹性成像（MRE）的快速和可重复的测量空间平均粘弹性常数的活人脑。该技术是基于相敏回波平面成像采集。运动编码与图像平面正交，并与头部摇杆致动器诱导的25和50 Hz驱动频率下的颅内剪切振动同步。在60 s内记录10个时间分辨的相位差波图像，并分析剪切刚度和剪切粘度。6名健康志愿者（6名男性;平均年龄34.5岁;年龄范围25-44岁）在6个月内接受了23-39项随访米泽研究。个体间平均SD剪切模量和剪切粘度分别为1.17 ± 0.03 kPa和3.1 ± 0.4 Pas（25 Hz）和1.56 ± 0.07 kPa和3.4 ± 0.2 Pas（50 Hz）（P
The purpose of this work was to develop magnetic resonance elastography (MRE) for the fast and reproducible measurement of spatially averaged viscoelastic constants of living human brain. The technique was based on a phase-sensitive echo planar imaging acquisition. Motion encoding was orthogonal to the image plane and synchronized to intracranial shear vibrations at driving frequencies of 25 and 50 Hz induced by a head-rocker actuator. Ten time-resolved phase-difference wave images were recorded within 60 s and analyzed for shear stiffness and shear viscosity. Six healthy volunteers (six men; mean age 34.5 years; age range 25-44 years) underwent 23-39 follow-up MIZE studies over a period of 6 months. Interindividual mean SD shear moduli and shear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/- 0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50 Hz, respectively (P