A biomechanical study of the recovery in spinal stability of flexion/extension and torsion after the resection of different posterior lumbar structures in a sheep model
A biomechanical study of the recovery in spinal stability of flexion/extension and torsion after the resection of different posterior lumbar structures in a sheep model
复制标题
羊模型不同后腰结构切除后脊柱屈伸扭转稳定性恢复的生物力学研究
DOI：
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Xinlong Ma
中科院分区：
文献类型：
--
作者：
H. Jia;Shao;Jian;Jie Wang;Rui Feng;D. Xing;Yang Yang;Bao;Y. Chen;Jingtao Yu;Xinlong Ma
腰椎后部结构对脊柱稳定性至关重要，许多研究者认为椎板切除术和小关节切除术会导致严重的脊柱不稳。然而，由于生物体具有补偿性修复能力，它们在受伤后的长期状况可能会随着时间的推移而改变。为了研究各种后部结构切除后不同时间点腰椎屈曲/伸展和扭转的生物力学稳定性的变化，以及评估自我愈合的能力，将接受椎板切除术或关节突切除术的绵羊用作实验动物模型。动物模型分为单纯椎板切除组、椎板切除加左侧关节突全切除组和椎板切除加双侧关节突全切除组。8只非手术绵羊作为对照组。分别于伤后0、6、12、24、36周取腰椎标本，采用Instron 8874伺服液压生物力学测试系统进行生物力学测试。并通过影像学检查分析损伤腰椎的变化。三种手术方式均严重降低了腰椎的屈曲/伸展和扭转稳定性。6周后，屈曲/伸展力学参数基本恢复;每个参数在12周时恢复到正常水平，并在24周和36周时超过完整组。扭转刚度也随时间逐渐恢复。所有损伤组均表现出手术节段或相邻节段的椎间隙缩小和小关节退变甚至融合。这些结果表明，机体在一定程度上具有修复力学失稳的能力。
Posterior lumbar structures are vital for spinal stability, and many researchers thought that laminectomy and facetectomy would lead to severe spinal instability. However, because living organisms have compensatory repair capacities, their long-term condition after injuries may change over time. To study the changes in the lumbar biomechanical stability of flexion/extension and torsion at different time points after the resection of various posterior structures, as well as to assess the capacity for self-healing, sheep that had undergone laminectomy or facetectomy were used as an experimental animal model. The injured sheep models included three groups: laminectomy only, laminectomy plus left total facetectomy, and laminectomy plus bilateral facetectomy. Eight nonoperative sheep were used as the control group. At 0, 6, 12, 24, and 36 weeks after injury, the lumbar specimens were harvested for biomechanical testing using the Instron 8874 servohydraulic biomechanical testing system. The changes in the injured lumbar spine were also analyzed through radiological examination. The lumbar stability in flexion/extension and torsion was severely decreased after the three types of surgery. After 6 weeks, the flexion/extension mechanical parameters recovered substantially; each parameter had returned to normal levels by 12 weeks and exceeded the intact group by 24 and 36 weeks. Torsional stiffness also recovered gradually over time. All injury groups demonstrated decreased intervertebral space and degeneration or even fusion in the small joints of the surgical segment or in adjacent segments. These results indicate that the body has the ability to repair the mechanical instability to a certain extent.
DOI：
10.1097/00002517-199212000-00001
发表时间：
1992-12-01
期刊：
JOURNAL OF SPINAL DISORDERS
影响因子：
--
作者：
PANJABI, MM
通讯作者：
PANJABI, MM
影响因子：
2.4
作者：
SCHENDEL, MJ;WOOD, KB;OGILVIE, JW
通讯作者：
OGILVIE, JW