Polyphenols and type 2 diabetes: A prospective review
Polyphenols and type 2 diabetes: A prospective review
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DOI：
10.1016/j.phanu.2013.07.004
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发表时间：
2013-10-01
期刊：
影响因子：
3.2
通讯作者：
Marette, Andre
中科院分区：
文献类型：
--
作者：
Anhe, Fernando F.;Desjardins, Yves;Marette, Andre
营养超负荷和久坐不动的生活方式与2型糖尿病（T2D）患病率的增加直接相关。然而，富含水果和蔬菜的饮食与T2D的发病率呈负相关，这些有益作用主要归因于酚类化合物。使用最有前途的富含多酚的食物来改善T2D的人类研究并不像体外和动物研究所指出的那样成功，这证明需要新的方法来缩小目前的差距。然而，现代技术不仅优化了酚类代谢物的提取和表征，而且还可以更好地了解多酚对肠道微生物群的影响。在这篇文章中，我们提供了一个概述的机制，涉及多酚的有益代谢作用，我们强调的代谢组的调查与富含多酚的食物的摄入。这些策略将有助于从各种水果和植物中鉴定出具有生物活性的酚类代谢物，从而发现新的品种，以产生针对T2D的更有效的功能性食品和营养品。(C)2013年由Elsevier B.V.出版
Nutritional overload and a sedentary life-style are directly associated with the growing prevalence of type 2 diabetes (T2D). However, a diet rich in fruits and vegetables is inversely correlated to the incidence of T2D, being these beneficial effects largely attributed to phenolic compounds. Human studies using the most promising polyphenol-rich foods to ameliorate T2D have not been as successful as in vitro and animal studies have pointed out, evidencing the need for new approaches in order to reduce this current gap. Nevertheless, modern techniques have not only optimized the extraction and the characterization of phenolic metabolites, but have also allowed a better understanding of the impact of polyphenols on the gut microbiota. In this article we provide an overview of the mechanisms implicated in the beneficial metabolic effects of polyphenols and we highlight the investigation of the metabolomes associated to the ingestion of polyphenol-rich foods. These strategies will help in the identification of bioactive phenolic metabolites from various fruits and plants, leading to the discovery of novel cultivars to generate more potent functional foods and nutraceuticals against T2D. (C) 2013 Published by Elsevier B.V.