BIOSYNTHESIS OF FLUOROTHREONINE AND FLUOROACETIC ACID BY THE THIENAMYCIN PRODUCER, STREPTOMYCES-CATTLEYA
BIOSYNTHESIS OF FLUOROTHREONINE AND FLUOROACETIC ACID BY THE THIENAMYCIN PRODUCER, STREPTOMYCES-CATTLEYA
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DOI：
10.7164/antibiotics.39.259
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发表时间：
1986-02-01
影响因子：
3.3
通讯作者：
INAMINE, E
中科院分区：
文献类型：
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作者：
SANADA, M;MIYANO, T;INAMINE, E
一种抗代谢物，THX，是从硫霉素生产商，链霉菌cattleya的发酵液中分离出来的，当该生物体在含氟底物的存在下生长时。THX随后被鉴定为4-氟代噻吩的四种可能的立体异构体之一。无机氟化物或多种有机氟化合物中的任何一种可用作4-氟噻吩的前体。此外，19 F NMR提供了生物体在相同发酵条件下合成氟乙酸的证据。本文还介绍了4-氟代菊酯的体外抗菌谱。
An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate. THX was subsequently identified as one of the four possible stereoisomers of 4-fluorothreonine. Inorganic fluoride or any one of a number of organofluorine compounds can be used as precursors of 4-fluorothreonine. In addition, 19F NMR has provided evidence that the organism synthesizes fluoroacetate under the same fermentation conditions. The in vitro antibacterial spectrum of 4-fluorothreonine is also presented.