INTRAVITREAL TRIAMCINOLONE INJECTION FOR TREATMENT OF MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSION
INTRAVITREAL TRIAMCINOLONE INJECTION FOR TREATMENT OF MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSION
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玻璃体内注射曲安奈德治疗继发于视网膜分支静脉阻塞的黄斑水肿
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Michael D. Ober
中科院分区：
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作者：
O. Çekiç;Stanley Chang;J. Tseng;G. Barile;L. D. Del Priore;H. Weissman;W. Schiff;Michael D. Ober
目的：评价玻璃体内注射曲安奈德治疗视网膜分支静脉阻塞（BRVO）所致黄斑水肿2年的疗效。研究方法：作者对13例患者（平均年龄68岁）的13只眼进行了回顾性病历审查，这些患者接受了4 mg曲安奈德玻璃体内注射治疗BRVO所致黄斑水肿。六只眼睛接受了单次注射。在一只眼睛中进行重复注射两次，四只眼睛三次，两只眼睛四次。平均随访时间为13个月（范围：4 - 24）。症状发作和注射之间的时间平均为7.4个月（范围，2至24）。结果：注射后中心凹厚度平均值为注射前的56%（529 m对295 m，P <0.001）。&mgr;&mgr;与基线相比，7只眼的最终视力改善（范围2 - 6 Snellen线），4只眼保持不变（范围0 - 1 Snellen线），2只眼恶化（范围-1-4 Snellen线）。所有病例的视网膜厚度均降低，大多数病例视力改善。随着注射次数的增加，白内障的变化也在增加。视力改善与患者年龄显著相关（P = 0.026）。8例患者发生类固醇诱导的高眼压，经局部药物治疗控制。根据光学相干断层扫描或荧光素血管造影，在接受手术的五只眼睛中，有三只眼睛的白内障摘除术被判定为加重了黄斑水肿。注射后中位最佳视力（20/50）显著优于基线（20/100）（P = 0.028）和末次随访（20/70）（P = 0.003）。结论：玻璃体内注射曲安奈德作为BRVO相关性黄斑水肿的一种治疗选择应进一步评估。
Purpose: To evaluate the efficacy of intravitreal triamcinolone injection in eyes with macular edema due to branch retinal vein occlusion (BRVO) over a 2-year period. Methods: The authors performed a retrospective chart review of 13 eyes of 13 patients (mean age 68 years) who underwent intravitreal injections with 4 mg triamcinolone acetonide for macular edema due to BRVO. Six eyes received a single injection. Repeated injections were performed in one eye twice, four eyes three times, and two eyes four times. Mean follow-up was 13 months (range, 4 to 24). The time between the onset of symptoms and the injection averaged 7.4 months (range, 2 to 24). Results: Mean postinjection central foveal thickness decreased to 56% of preinjection values (529 &mgr;m versus 295 &mgr;m, P < 0 .001). Final visual acuity improved in seven eyes (range 2 to 6 Snellen lines), remained the same in four eyes (range 0 to 1 Snellen lines), and worsened in two eyes (range −1 to −4 Snellen lines) compared to baseline. The retinal thickness decreased in all cases; vision improved in most cases. As the number of injections increased cataractous changes increased. Visual acuity improvement was significantly correlated with patient age (P = 0.026). Eight patients developed steroid induced ocular hypertension controlled by topical medication. Cataract extraction was judged to aggravate macular edema in three of the five eyes undergoing surgery, based upon optical coherence tomography or fluorescein angiography. Median best postinjection visual acuity (20/50) was significantly better than that of baseline (20/100) (P = 0.028) as well as last follow-up (20/70) (P = 0.003). Conclusions: Intravitreal triamcinolone should be further evaluated as a treatment option for macular edema associated with BRVO.