Assisted reproductive technologies and the risk of congenital urogenital tract malformations: A systematic review and meta-analysis
Assisted reproductive technologies and the risk of congenital urogenital tract malformations: A systematic review and meta-analysis
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DOI：
10.1016/j.jpurol.2020.11.005
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发表时间：
2021
影响因子：
2
通讯作者：
Guanghui Wei
中科院分区：
文献类型：
--
作者：
Zhi-Cheng Zhang;Xing Liu;Chun Wei;Jin Luo;Yan Shi;Tao Lin;Dawei He;Guanghui Wei
Summary A systematic review was conducted to evaluate the relationship between ART and the risk of urogenital tract malformations, especially hypospadias and cryptorchidism. Thirty-three papers were selected. Meta-analysis showed that ART was correlated with an increased risk of urogenital tract malformation in offspring (odds ratio (OR) = 1.61, 95% confidence interval (CI): 1.41–1.85), hypospadias (OR = 1.87, 95% CI: 1.47–2.40) and cryptorchidism (OR = 1.83, 95% CI: 1.54–2.18). Among offspring conceived by ART, multiple pregnancies appeared to result in a higher risk of urogenital tract malformation than singleton pregnancies (OR = 1.42, 95% CI: 0.99–2.04; P = 0.058). No significant difference in the risk of urogenital tract malformation was found between in vitro fertilization and intracytoplasmic sperm injection technologies. A sensitivity analysis showed that the above conclusions were relatively consistent. Conclusion: ART is correlated with an increased risk of urogenital tract malformations in offspring, especially hypospadias and cryptorchidism. Among ART offspring, multiple pregnancies may lead to a higher risk of urogenital tract malformations than singleton pregnancies, but more studies are needed for confirmation.
