The host cytosol: front-line or home front?

The host cytosol: front-line or home front?
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宿主细胞质:前线还是后方?

DOI:
10.1016/s0966-842x(02)02401-0
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发表时间:
2002
影响因子:
15.9
通讯作者:
Portnoy,DanielA
Portnoy,DanielA
中科院分区:
生物学1区
文献类型:
--
作者:
O'Riordan,Mary;Portnoy,DanielA

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胞内病原体在宿主细胞的修饰的液泡区室或胞质溶胶中复制。许多致病细菌物种已经进化到改变宿主液泡环境,但对哺乳动物细胞质作为细菌生长的介质知之甚少。最近的研究表明,胞质溶胶是限制细菌的生长,而不是胞质病原体,与早期的研究,提供证据表明,任何细菌可以访问胞质溶胶可以复制。这些研究的比较表明,不同类型的宿主细胞的胞质内容物可以差异允许细菌生长,宿主和细菌的因素是重要的,在确定特定的细菌在胞质中复制的能力。
Intracellular pathogens replicate in modified vacuolar compartments or in the cytosol of host cells. Many pathogenic bacterial species have evolved to modify the host vacuolar environment, but little is known about the mammalian cytosol as a medium for bacterial growth. Recent studies indicate that the cytosol is restrictive for the growth of bacteria other than cytosolic pathogens in contrast to earlier research that provided evidence that any bacteria with access to the cytosol can replicate there. Comparison of these studies suggests that the cytosolic contents of various host cell types can be differentially permissive for bacterial growth, and that both host and bacterial factors are important in determining the ability of particular bacteria to replicate in the cytosol.
DOI: 10.1038/345175a0
发表时间: 1990-05-10
期刊: NATURE
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DOI: --
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