Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density
Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density
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DOI：
10.7554/elife.34463
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发表时间：
2018-05-31
期刊：
影响因子：
7.7
通讯作者：
Bousema, Teun
中科院分区：
文献类型：
--
作者：
Bradley, John;Stone, Will;Bousema, Teun
了解配子体密度对人-蚊传播的重要性对疟疾控制具有直接意义。先前的工作（Churcher等人，2013）表明配子体密度和蚊子感染之间的复杂关系。在这里，我们使用的数据，从148自然感染配子体载体喂养实验表明，关系要简单得多，并取决于女性和男性寄生虫密度。受感染蚊子的比例主要由雌性配子体的密度决定，尽管低配子体密度的传播可能因缺乏雄性寄生虫而受阻。提高配子体定量的精确度简化了与感染的关系的形状，在较高密度下达到稳定之前迅速增加。每只蚊子的平均卵囊数随着配子体密度的增加而迅速增加，但在检查的密度范围内继续增加。这项工作强调了在估计人类感染库时测量女性和男性配子体密度的重要性。
Understanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a complex relationship between gametocyte density and mosquito infection. Here we use data from 148 feeding experiments on naturally infected gametocyte carriers to show that the relationship is much simpler and depends on both female and male parasite density. The proportion of mosquitoes infected is primarily determined by the density of female gametocytes though transmission from low gametocyte densities may be impeded by a lack of male parasites. Improved precision of gametocyte quantification simplifies the shape of the relationship with infection increasing rapidly before plateauing at higher densities. The mean number of oocysts per mosquito rises quickly with gametocyte density but continues to increase across densities examined. The work highlights the importance of measuring both female and male gametocyte density when estimating the human reservoir of infection.