THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION
THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION
复制标题
DOI：
10.1073/pnas.89.16.7840
复制
发表时间：
1992-08-15
影响因子：
11.1
通讯作者：
DARNELL, JE
中科院分区：
文献类型：
--
作者：
FU, XY;SCHINDLER, C;DARNELL, JE
ISGF-3是一种多蛋白质转录因子，仅在干扰素α附着于细胞表面后才在细胞质中被非常快速地激活。为了了解移动到细胞核的蛋白质的特异性细胞质激活和特定基因的直接增加的转录，我们已经纯化，现在报告完成了编码ISGF-3的四种蛋白质的cDNA的克隆。有了所有可用的序列，很明显，这些蛋白质中的三个是由以前未被识别的基因家族的成员编码的。我们认为，由这个基因家族编码的蛋白质的功能解释的事实，即细胞表面受体结合其配体，使特定的信号转导到细胞核可以发生。
ISGF-3 is a multiprotein transcription factor that is very quickly activated in the cell cytoplasm only after attachment of interferon a to the cell surface. To understand the specific cytoplasmic activation of proteins that move to the nucleus and direct increased transcription of specific genes, we have purified and now report completion of the cloning of cDNA encoding the four proteins of ISGF-3. With all of the sequences available, it is clear that three of these proteins are encoded by members of a previously unrecognized gene family. We suggest that proteins encoded by this gene family serve the function of interpreting the fact that a cell surface receptor has bound its ligand so that specific signal transduction to the nucleus can occur.