Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort study
Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort study
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DOI：
10.1016/s0140-6736(02)11470-x
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发表时间：
2002-11-09
期刊：
影响因子：
168.9
通讯作者：
Marmot, M
中科院分区：
文献类型：
--
作者：
Malyutina, S;Bobak, M;Marmot, M
研究背景：适量饮酒与心血管疾病死亡率降低有关，但酗酒被认为是有害的。我们研究了大量饮酒和狂欢饮酒对狂欢饮酒率高的人群的影响。方法我们在俄罗斯新西伯利亚进行了一项前瞻性队列研究，研究对象为6502名基线年龄在25-64岁之间的男性，（监测心血管疾病调查中的趋势和决定因素），1985/86年、1988/89年和1994/95年以及1984年的一项试点研究。我们通过问卷调查评估了酒精摄入量和饮酒模式;狂欢饮酒定义为在典型场合消费160 g或更高的纯酒精。参与者随访中位数为9.5年（范围3.1-15.2）。结果有836例死亡的队列，其中395例导致心血管疾病。基线时酗酒的患病率为16%（n=1005）。调整后的相对风险，酗酒至少每月一次（与消费相比，
Background Moderate alcohol consumption is associated with reduced cardiovascular mortality, but binge drinking is thought to be detrimental. We examined effects of heavy and binge drinking in a population with high rates of binge drinking.Methods We did a prospective cohort study in Novosibirsk, Russia, in 6502 men aged 25-64 years at baseline who were examined in WHO MONICA (monitoring trends and determinants in cardiovascular disease surveys) in 1985/86, 1988/89, and 1994/95, and in a pilot study in 1984. We assessed alcohol intake and drinking pattern by questionnaire; binge drinking was defined as consumption of 160 g or greater of pure alcohol on a typical occasion. Participants were followed-up for a median of 9.5 years (range 3.1-15.2).Findings There were 836 deaths in the cohort, 395 of which resulted from cardiovascular diseases. Prevalence of binge drinking at baseline was 16% (n=1005). Adjusted relative risks for binge drinking at least once a month (compared with consumption of