Inhibitory activity of soyasaponin II on virus replication in vitro
Inhibitory activity of soyasaponin II on virus replication in vitro
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DOI：
10.1055/s-2006-957622
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发表时间：
1997-04-01
期刊：
影响因子：
2.7
通讯作者：
Ikeshiro, Y
中科院分区：
文献类型：
--
作者：
Hayashi, K;Hayashi, H;Ikeshiro, Y
体外研究了从大豆 (Glycine max Merrill) 中分离的两种皂苷（大豆皂苷 I 和 II）对 1 型单纯疱疹病毒 (HSV-1) 的抗病毒活性。大豆皂苷 II 比大豆皂苷 I 更有效，如 HSV-1 产量减少所示。大豆皂苷 II 还被发现可以抑制人类巨细胞病毒、流感病毒和人类免疫缺陷病毒 1 型的复制。这种作用并非由于抑制病毒渗透和蛋白质合成，而是可能涉及杀病毒作用。当评估阿昔洛韦和大豆皂苷 II 组合的抗 HSV-1 活性时，观察到对该病毒的附加抗病毒作用。
The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1. The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. When acyclovir and soyasaponin II were evaluated in combination for anti-HSV-l activity, additive antiviral effects were observed for this virus.