A comparison of the firing properties of putative excitatory and inhibitory neurons from CA1 and the entorhinal cortex
A comparison of the firing properties of putative excitatory and inhibitory neurons from CA1 and the entorhinal cortex
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DOI：
10.1152/jn.2001.86.4.2029
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发表时间：
2001-10-01
影响因子：
2.5
通讯作者：
Wilson, MA
中科院分区：
文献类型：
--
作者：
Frank, LM;Brown, EN;Wilson, MA
内嗅皮层（EC）的浅层提供了大部分的新皮质输入到海马，和EC的深层接收大部分的新皮质绑定海马输出。为了表征通过海马和EC电路的信息传输，我们同时记录从神经元在表层EC，海马CA1区，和深EC，而啮齿动物跑食物奖励在两个环境中。棘波波形分析使我们能够将单位分类为快速尖峰（FS）推定的抑制性细胞或推定的兴奋性（PE）细胞。在短时间尺度上，PE和FS单位的放电通常是强相关的，这表明存在从PE到FS单位的单突触连接。EC PE单位，不像那些在CA1中发现的，表现出很少或没有倾向于在突发火灾。我们还发现，从所有区域的FS和PE单位的放电调制的类似8赫兹θ节律，虽然深EC FS单位的放电往往是不那么强烈的调制比其他类型的单位。当我们检查FS单位的空间特异性时，我们确定所有三个区域的FS单位均显示出低特异性。与此同时，追溯编码，其中发射率与过去的位置，是目前在FS单位从所有三个区域和深EC FS单位经常发射的“路径等效”的方式，他们活跃在物理上不同的，但行为相关的位置内和跨环境。我们的研究结果表明，虽然消防FS单位CAI和EC显示同样低水平的位置特异性，FS单位从每个区域彼此不同，因为他们反映了相关的PE单位在他们的倾向，以显示更复杂的位置发射属性，如回溯编码和路径等价。
The superficial layers of the entorhinal cortex (EC) provide the majority of the neocortical input to the hippocampus, and the deep layers of the EC receive the majority of neocortically bound hippocampal outputs. To characterize information transmission through the hippocampal and EC circuitry, we recorded simultaneously from neurons in the superficial EC, the CA1 region of hippocampus, and the deep EC while rodents ran for food reward in two environments. Spike waveform analysis allowed us to classify units as fast-spiking (FS) putative inhibitory cells or putative excitatory (PE) cells. PE and FS units' firing were often strongly correlated at short time scales, suggesting the presence a monosynaptic connection from the PE to FS units. EC PE units, unlike those found in CA1, showed little or no tendency to fire in bursts. We also found that the firing of FS and PE units from all regions was modulated by the similar to8 Hz theta rhythm, although the firing of deep EC FS units tended to be less strongly modulated than that of the other types of units. When we examined the spatial specificity of FS units, we determined that FS units in all three regions showed low specificity. At the same time, retrospective coding, in which firing rates were related to past position, was present in FS units from all three regions and deep EC FS units often fired in a "path equivalent" manner in that they were active in physically different, but behaviorally related positions both within and across environments. Our results suggest that while the firing of FS units from CAI and the EC show similarly low levels of position specificity, FS units from each region differ from one another in that they mirrored the associated PE units in terms of their tendency to show more complex positional firing properties like retrospective coding and path equivalence.