F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis
F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis
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DOI：
10.1097/mnm.0b013e32833e37c4
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发表时间：
2010-11-01
影响因子：
1.5
通讯作者：
Ichise, Masanori
中科院分区：
文献类型：
--
作者：
Provenzano, Frank Anthony;Jordan, Barry;Ichise, Masanori
目的：参加拳击等脑震荡易感运动可能导致慢性创伤性脑损伤。本研究的目的是确定职业拳击手和业余拳击手是否存在独特的脑葡萄糖代谢降低的模式。方法采用统计参数图和感兴趣区分析的方法，对19名拳击手(N=19)和7名对照组(N=7)的F-18氟脱氧葡萄糖(F-18 FDG)PET脑扫描进行比较。结果拳击手对F-18 FDG的摄取在以下脑区减少了8-15%：后扣带回、顶枕叶、双侧额叶(Broca‘s区)和小脑(P<；0.005)。结论疑似慢性颅脑损伤的拳击手的F-18FDGPET扫描显示出独特的低代谢模式，这些模式可能反映了拳击手特有的反复创伤性脑损伤的机制。Nucl Med Commun 31：952-957(C)2010 Wolters KluwerHealth|Lippincott Williams&Wilkins。
Purpose The participation in concussive susceptible sports such as boxing may cause chronic traumatic brain injury. The objective of this study was to determine whether there are unique patterns of reduced brain glucose metabolism in professional and amateur boxers.Method We compared the fluorine-18 fluorodeoxyglucose (F-18 FDG) PET brain scans of boxers (group) (N=19) with those of controls (group) (N=7) using both statistical parametric mapping and region of interest analysis.Results Boxers showed decreased F-18 FDG uptake by 8-15% in the following brain areas: posterior cingulate cortex, parieto-occipito, frontal lobes (Broca's area) bilaterally, and the cerebellum (P < 0.005) as compared with controls.Conclusion Our results suggest that F-18 FDG PET scans of boxers suspected of chronic traumatic brain injury show unique patterns of hypometabolism, and that these patterns may reflect the mechanisms of repeated traumatic brain injury unique to boxers. Nucl Med Commun 31: 952-957 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.