Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [13C] Urea Breath Test and Monoclonal H. pylori Stool Antigen Test
Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [13C] Urea Breath Test and Monoclonal H. pylori Stool Antigen Test
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DOI：
10.1128/jcm.01752-13
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发表时间：
2013-11-01
影响因子：
9.4
通讯作者：
Crabtree, Jean E.
中科院分区：
文献类型：
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作者：
Magalhaes Queiroz, Dulciene Maria;Saito, Mayuko;Crabtree, Jean E.
强烈需要准确的无创测试来诊断幼儿的幽门螺杆菌感染。我们研究了 [C-13] 尿素呼气试验 ([C-13] UBT) 与单克隆 ELISA (HpSA) 检测粪便中幽门螺杆菌抗原的一致性。从2007年10月到2011年7月，我们招募了414名6至30个月大的婴儿（123名来自巴西，291名来自秘鲁）。至少每隔 3 个月从巴西（n = 415）和秘鲁（n = 908）婴儿采集呼吸和粪便样本。 [C-13] 1,255 例 (94.86%) 病例中 UBT 和粪便检测结果一致（kappa 系数 = 0.90；95% 置信区间 [CI] = 0.87 至 0.92）。在幽门螺杆菌阳性组中，超基线增量 (DOB) 和光密度 (OD) 值呈正相关 (r = 0.62；P
Accurate noninvasive tests for diagnosing Helicobacter pylori infection in very young children are strongly required. We investigated the agreement between the [C-13] urea breath test ([C-13] UBT) and a monoclonal ELISA (HpSA) for detection of H. pylori antigen in stool. From October 2007 to July 2011, we enrolled 414 infants (123 from Brazil and 291 from Peru) of ages 6 to 30 months. Breath and stool samples were obtained at intervals of at least 3 months from Brazilian (n = 415) and Peruvian (n = 908) infants. [C-13] UBT and stool test results concurred with each other in 1,255 (94.86%) cases (kappa coefficient = 0.90; 95% confidence interval [CI] = 0.87 to 0.92). In the H. pylori-positive group, delta- over- baseline (DOB) and optical density (OD) values were positively correlated (r = 0.62; P