EFFECT OF NICOTINE, LOBELINE, AND MECAMYLAMINE ON SENSORY GATING IN THE RAT
EFFECT OF NICOTINE, LOBELINE, AND MECAMYLAMINE ON SENSORY GATING IN THE RAT
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DOI：
10.1016/0091-3057(94)90237-2
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发表时间：
1994-12-01
影响因子：
3.6
通讯作者：
DECKER, MW
中科院分区：
文献类型：
--
作者：
CURZON, P;KIM, DJB;DECKER, MW
在正常受试者中，如果声惊吓刺激之前立即发生背景噪声强度的短暂变化，则随后的惊吓反应的幅度会降低。这种声惊吓反应的前脉冲抑制（PPI）已被证明与感觉运动门控有关。PPI在精神分裂症患者中被破坏，并与这种疾病的注意力障碍特征有关。我们检测了（-）-尼古丁（0.19、0.62和1.9 pmol/kg IP）（相当于0.03、0.1和0.3 mg/kg碱）和烟碱胆碱能受体（nAChR）通道阻滞剂美加明（5.0和50 μ mol/kg IP）（相当于1.0和10.0 mg/kg）对大鼠声惊吓反应PPI的影响。尼古丁在最低的前脉冲信号水平下增加了PPI，但在较强的水平下没有增加。美加明在5.0 μ mol/kg剂量下没有作用，但50 pmol/kg剂量在弱和强前脉冲（PP）水平下均降低了抑制作用。美加明（5.0 μ mol/kg）预处理不能阻断（-）-尼古丁诱导的PPI升高。洛贝林（0.19、0.62、1.9和6.2 μ mol/kg IP）（相当于0.071、0.23、0.71和2.3 mg/kg）无作用。这些结果与尼古丁改善正常大鼠门控的美卡明胺不敏感效应一致。nAChR亚型参与产生尼古丁增加PPI需要进一步研究。
In normal subjects, if an acoustic startle stimulus is immediately preceded by a small brief change in background noise intensity, the magnitude of the subsequent startle response is decreased. This prepulse inhibition (PPI) of an acoustic startle response has been shown to be associated with sensorimotor gating. PPI is disrupted in schizophrenic patients and has been linked to attentional disorders characteristic of this disease. We tested the effects of (-)-nicotine, (0.19, 0.62, and 1.9 pmol/kg IP) (equivalent to 0.03, 0.1, and 0.3 mg/kg base) and the nicotinic cholinergic receptor (nAChR) channel blocker, mecamylamine (5.0 and 50 mu mol/kg IP) (equivalent to 1.0 and 10.0 mg/kg) on PPI of the acoustic startle response in the rat. Nicotine increased the PPI at the lowest prepulse signal levels but not at the stronger levels. Mecamylamine was without effect at 5.0 mu mol/kg, but the 50 pmol/kg dose decreased the inhibition at both weak and strong prepulse (PP) levels. Mecamylamine (5.0 mu mol/kg) pretreatment did not block the (-)-nicotineinduced increase in PPI. Lobeline (0.19, 0.62, 1.9, and 6.2 mu mol/kg IP) (equivalent to 0.071, 0.23, 0.71, and 2.3 mg/kg) was without effect. These results are consistent with a mecamylamine-insensitive effect of nicotine to improve gating in normal rats. The nAChR subtype involved in producing nicotine's increase of PPI needs further investigation.